摘要
PHD-finger蛋白是一类广泛存在于真核生物中,在基因转录和染色质状态调控方面有重要作用的锌指蛋白。目前在动物中对PHD-finger蛋白的结构和功能方面的研究较为广泛和深入,而在植物中仅有少数PHD-finger蛋白的功能被阐明。通过SMART和Pfam等数据库分析,我们发现拟南芥中共有70个PHD-finger蛋白,其中大部分PHD-finger蛋白的功能未知。本文通过生物信息学分析获得拟南芥PHD-finger家族较为全面的信息,包括基因结构、染色体定位、基因表达、蛋白结构域、系统进化关系等,为深入研究PHD-finger家族蛋白的结构与功能提供了参考。
PHD-finger proteins were found universally in eukaryotes and known as key players in regulating chromatin or transcription. In animals, many PHD-finger proteins had been well studied on structure and function. Compared to animals, only a few of plant PHD-finger proteins had been characterized functionally. By both SMART and Pfam searches, 70 members of the PHD-finger family were identified in Arabidopsis thaliana. Most of the PHD-finger proteins in Arabidopsis thaliana were functionally unknown. A complete overview of this family by bioinformatic approach were presented in this paper, including the gene structure, gene localization in genome, gene expression, protein motif organization, and phylogenetic relationship of each family member. These results should provide useful information for the further structural and functional studies of PHD-finger proteins.
出处
《云南植物研究》
CSCD
北大核心
2009年第3期227-238,共12页
Acta Botanica Yunnanica
基金
国家自然科学基金项目(30671127)
上海师范大学科研项目(sk200827)
