摘要
目的观察乌司他丁对老年患者直肠癌根治术肝肾功能的影响。方法选择直肠癌根治术老年患者40例,随机分为乌司他丁组20例和生理盐水组20例。乌司他丁组在术前、术后1-3天每天予乌司他丁20万u静脉滴注,生理盐水组仅生理盐水静脉滴注。同期检测乌司他丁组和生理盐水组手术前后肝肾功能。结果乌司他丁组患者术后72 h丙氨酸氨基转移酶（ALT）和天冬氨酸氨基转移酶（AST）明显低于生理盐水组,尿素氮（BUN）和血清肌酐（Cr）也明显低于生理盐水组（P〈0.05）。结论乌司他丁可较好地保护直肠癌根治术老年患者的肝肾功能,并能减少术后并发症。
Objective To observe and analyze the Ulinastatins＇protective effects on postoperative liver and renal function of the elderly patients undergoing radical resection of rectal carcinoma. Methods Forty elderly patients undergoing radical resection of rectal carcinoma during the same period were selected and randomly divided into 2 groups ： treatment group and control group. In treatment group, the patients were subjected to the intravenous drip of normal saline plus Ulinastatin （ 2.0 × 10^5u ） before operation and perday on the postoperative day 1 - 3, and those in control group only to normal saline . The liver and renal function pre - and post - operation were determined and compared in the two groups. Results Serum ALT and AST levels in treatment group were significantly lower than those in control group 72 hours post - operation ; and serum BUN and Cr levels in treatment group were significantly lower than those in control group 72 hours post - operation （ P 〈 0.05 ）. Conclusion Ulinastatin could play certain role in protecting the function of liver and kidney and decrease postoperative complications.
出处
《南华大学学报（医学版）》
2009年第2期217-219,共3页
Journal of Nanhua University(Medical Edition)
关键词
乌司他丁
直肠癌
肝功能
肾功能
ulinastatin
rectal cancer
liver function
renal function
