摘要
背景与目的已有研究表明：非小细胞肺癌（non-small cell lung cancer, NSCLC）患者手术切除原发肿瘤后其血清中血管内皮生长因子（vascular endothelial growth factor, VEGF）浓度显著升高，血小板可能是血清中VEGF的主要来源。本研究的目的是探讨NSCLC患者术后血清VEGF浓度的动态变化及其与血小板之间的关系。方法应用酶联免疫吸附试验（enzyme linked immunosorbent assay, ELISA）检测法，监测76例非小细胞肺癌患者术前、术后1天及7天血清VEGF的浓度，同期检测血小板的浓度。结果①NSCLC患者术前、术后1天及7天血清VEGF分别为（842．06±52724）pg／mL、（1119．28±609．62）pg／mL、（1574．09±873．38）pg／mL，组间比较差异具有统计学意义（P=0．000）；②NSCLC患者术前、术后1天及7天血小板计数分别为（230．42±82．56）×10^0/L、（196．47±8148）×10^9/L、（237．90~86．94）×10^9/L，术后1天最低（P=0．000），③术后7天在血小板高于均数组血清VEGF浓度为（1842．86±1006．63）pg／mL，低于均数组为（1398．81±734．00）pg／mL，两组有统计学差异（P=0．043）。结论NSCLC患者术后血清VEGF浓度显著升高，血小板计数高的患者中，其血清VEGF浓度升高更为明显。
Background and objective It has been proven that serum vascular endothelial growth factor （VEGF） concentration was elevated significantly after surgery in patients with non-small cell lung cancer （NSCLC） . Platelet maybe the main resource of serum VEGF. The aim of this study is to investigate the correlation between postoperative dynamic changes of serum VEGF levels and platelet counts in patients with NSCLC who underwent surgery. Methods Serum VEGF levels were determined in 76 patients with NSCLC who were treated with surgery by ELISA （enzyme linked immunosorbent assay） method before operation and on postoperative day 1, 7. At the same day the concentrations of platelet were determined. Results ① Serum VEGF in patients with NSCLC on preoperative day, postoperative 1 day and 7 day were （842.06 ±527.24） pg/mL, （1119.28±609.62） pg/mL, （1574.09±873.38） pg/mL, respectively （P= 0.000） ②Platelet counts in patients with NSCLC on preoperative day, postoperative 1 day and 7 day were （230.42±82.56） × 10^9/L, （196.47±81.48）× 10^9/L, （237.90±86.94） ×10^9/L; the value on postoperative 1 day was the lowest （P = 0.1300） ; ③On postoperative 7 day, serum VEGF in the group of lower than the mean and higher than the mean were respectively （ 1398.81±734.00） pg/mL and （ 1842.86 ±1006.63） pg/mL （P = 0.043） . Conclusions Serum VEGF in patients with NSCLC after surgery were elevated. In the group of higher platelet counts, serum VEGF increased more significantly.
出处
《结核病与胸部肿瘤》
2010年第1期25-29,共5页
Tuberculosis and Thoracic Tumor
关键词
癌
非小细胞肺
血管内皮生长因子
酶联免疫吸附试验
手术
血小板
Carcinoma, non-small cell lung Vascular endothelial growth factor （VEGF） Enzyme linked immanosorbent assay （ELISA）Surgery Platelet
