摘要
目的 :探讨应用乌司他丁对胃肠癌患者术后机体免疫功能的影响 .方法 :选择行胃肠癌根治性手术患者 4 6例 ,随机分为实验组 (n =2 3)和对照组 (n =2 3) .实验组在手术当日起至术后 6d ,每日给予 2 0万U乌司他丁 (UTI)静脉注射 ;对照组则以等量生理盐水静脉注射 .检测和分析术前、术后不同时期的免疫功能指标 (包括CD3+ ,CD4 + ,CD8+ ,CD4 + /CD8+ ,NK细胞、IL 2 ,IgA ,IgG和IgM等指标 ) .结果 :两组患者的CD3+ 细胞、CD4 + 细胞、CD4 + /CD8+ 比值、NK细胞活性以及血清IgG ,IgM ,IgA ,IL 2水平表现为术后 1d降低 ,术后 4d ,7d逐渐回升的趋势 .实验组和对照组比较 ,CD4 + 细胞、CD4 + /CD8+ 比值、NK细胞活性以及血清IgG ,IgM ,IL 2水平存在统计学差异 (P <0 .0 5 ) .结论
AIM: To evaluate the effects of urinary trypsin inhibitor (UTI) on the immune function of patients with gastrointestinal cancer after operation. METHODS: Forty six patients with gastrointestinal cancer were randomly divided into UTI group ( n =23), and control group ( n =23). In UTI group, 2×10 5 U UTI was administered daily, from the day of surgery to the 6th d after radical operation. Test of the immune function (CD3 +, CD4 +, CD8 +, CD4 +/CD8 +, NK cell, IL 2, IgA, IgG, IgM) was performed preoperatively and at different time periods postoperatively. RESULTS: The tendency of CD3 +, CD4 +, CD4 +/CD8 + ratio, NK cell, IL 2, IgA, IgG and IgM descended on day 1 after operation, and rose again on d 4 and d 7 after operation in the two groups. The difference of CD4 +, CD4 +/CD8 +, NKC activity, IgG, IgM and IL 2 level was significant between the experimental group and control group ( P <0.05). CONCLOSION: UTI can significantly improve the immune function in patients with gastrointestinal cancer after operation.
出处
《第四军医大学学报》
北大核心
2004年第15期1435-1437,共3页
Journal of the Fourth Military Medical University
关键词
乌司他丁
胃肠肿瘤
免疫功能
外科学
urinary trypsin inhibitor
gastrointestinal neoplasms
immune function
surgery
