摘要
目的探讨肠内营养对梗阻性黄疸幼鼠肝功能和形态结构的影响。方法将40只W istar大鼠随机分为正常对照组、假手术组、梗阻性黄疸(OJ)组、OJ+能全素组。OJ+能全素组给予肠内营养10 d,总热量为610 kJ/(kg.d),氮量1.0 g/(kg.d)。检测实验鼠肝功能指标中的丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、直接胆红素(DB il)和总胆汁酸(TBA)浓度,并对肝脏组织进行病理形态学观察。结果OJ组、OJ+能全素组肝功能指标中AST、ALT、DB il、TBA水平显著高于正常对照组和假手术组,OJ+能全素组上述指标较OJ组显著降低。OJ+能全素组肝脏形态学改变较OJ组有所减轻。结论肠内营养有助于改善梗阻性黄疸幼鼠的肝功能指标和形态学结构。
Objective To evaluate the effects of enteral nutrition on liver function and morphology in immature rats with obstructive jaundice （ OJ ）. Methods Sixty immature male Wistar rats were randomly divided into normal control group, sham operation group, OJ group,and OJ ＋ Nutrison group, in OJ ＋ Nutrison gruup,nutritional formulae were given to the rats for ten days. Total calorie was 610 kJ/（ kg · d） and nitrogen amount was 1.0 g/（ kg · d）. Serum alanine aminotransferase （ ALT） ,aspcrtate aminotransferase （ AST） ,direct bilirubin （ DBil） ,and total bile acid （TBA） levels were detected. Hepatic morphological findings were also observed. Results Entcral nutrition maintained liver function parameters better than normal diet in OJ rats and slightly affected hepatic morphology. Conclusion Enteral nutrition improves liver function and hepatic morphology in immature rats with OJ.
出处
《滨州医学院学报》
2006年第2期81-83,共3页
Journal of Binzhou Medical University
基金
山东省中医药科技发展计划项目(2005-002)
关键词
梗阻性黄疸
肠内营养
肝功能
肝脏病理学
obstructive jaundice, enteral nutrition, liver function, hepatic histopathology
