摘要
目的探讨MMP-2、MMP-9、Fas、HIF-lα、VEGF在肺癌组织中的表达,研究其与肺癌的侵袭和转移的关系。方法对我院经根治性切除的肺癌,术后得到病理证实患者,进行肺癌侵袭和转移相关因子研究,采用肺癌组织石蜡切片进行免疫组化分析。结果研究发现69例肺癌组织中MMP-2、MMP-9、Fas、HIF-lα、VEGF蛋白阳性表达总蹬阳性率分别为86.9%、88.4%、57.9%、81.2%、82.6%,其蛋白的阳性表达与临床分期、复发转移、分化程度等密切相关。结论MMP-2、MMP-9、Fas、HIF-lα、VEGF蛋白表达与肺癌侵袭与转移机制关系密切,尝可能成为判断肺癌治疗效果和预后的可靠指标之一。
Objective To observe the expressions of MMP-2, MMP-9, Fas, HIF-1α, VEGF in bronchogenic carcinoma tissue, and to investigate the relationship between these factors and invasion as well as metastasis of bronchogenic carcinoma. Methods 69 patients who were enrolled in our hospital were treated with radical excision and identified as bronchogenic carcinoina by pathology. The expressions of MMP-2, MMP-9, Fas, HIF-1α, VEGF were detected by method. Results The positive expression rates of MMP-2, MMP-9, Fas, HIF-1α, VEGF in bronchogenic carcinoma tissue were 86.9%, 88.4%, 57.9%, 81.2%, 82.6%, respectively. The expression levels were related with clinical stage, palindromia or metastasis, histological differentiation. Conclusion The expression of MMP-2, MMP-9, Fas, HIF-1α, VEGF in brenchogenic carcinoma tissue is closely related with the invasion and metastasis mechanism of bronchogenic carcinoma, which can serve as one of the indexes for evaluating the therapeutic effect and prognosis in patients with bronchogenic carcinoma.
出处
《河北医药》
CAS
2009年第8期904-906,共3页
Hebei Medical Journal
关键词
肺癌
侵袭
转移
机制
bronchogenic carcinoma
invasion
metastasis
mechanism
