摘要
目的:评价家兔经口给药槐果碱和槐定碱的药动学。方法:建立反相高效液相色谱法,评价家兔经口给药槐果碱和槐定碱的药动学。结果:家兔经口给药槐果碱和槐定碱后,体内过程都符合二室、一级吸收、有滞后时间模型,模型权重为1/C/C。槐果碱的分布和消除速度都比槐定碱快。结论:家兔空腹单次经口给药槐果碱和槐定碱后,槐果碱的AUC低于槐定碱;槐果碱的分布和消除速度都比槐定碱快。
Objective： To evaluate the pharmacokinetic properties of single dose of sophocarpine and sophoridine in rabbit. Methods： RP-HPLC method was used for determining sophocarpine and sophoridine in rabbit plasma, and the pharmacokinetic parameters following oral administration were calculated. Results： The plasma drug concentration-time curve after oral administration of a dose of 200 mg·kg^-1 sophocarpine or sophoridine fitted to a two-compartmant model, first order absorption, lag time model with weights of 1/C/C in rabbits. The absorption and elimination rates of sophocarpine were faster than those of sophoridine. Conclusion： Following oral administration in rabbits, the AUC for sophocarpine was lower than that for sophoridine, and the absorption and elimination rates of sophocarpine were faster than those of sophoridine.
出处
《中国新药杂志》
CAS
CSCD
北大核心
2009年第8期759-762,共4页
Chinese Journal of New Drugs
基金
国家自然科学基金资助项目(30572181)
关键词
槐果碱
槐定碱
药动学
sophocarpine
sophoridine
pharmacokinetles
