摘要
目的研究槐定碱(sophoridine,SRI)对家兔血流动力学的影响。方法将32只家兔随机分为四组,即槐定碱2.5、5、10mg/kg及生理盐水对照组。采用经典的血流动力学方法观察给药前与给药后0、1、3、5、7、10min的心率(HR)、收缩压(SP)、舒张压(DP)、左心室收缩压(LVSP)、左心室终末舒张压(LVEDP)、左心室内压最大上升速率(dp/dtmax)、左心室开始收缩至dp/dtmax的间隔时间(t-dp/dtmax)、心室内压最大下降速率(-dp/dtmax)和等容舒张时间室内压下降的时间常数(T)的变化,并与对照组比较。结果(1)SRI对家兔心率和血压的影响:与对照组比较,静脉注射SRI 2.5mg/kg对心率无明显影响(P>0.05);5mg/kg在1min时明显减慢心率(P<0.05),10mg/kg能使家兔心率显著减慢(P<0.01)。SRI 2.5mg/kg能增加SP(P<0.05),对DP无明显影响;5mg/kg明显增加SP、DP(P<0.01或P<0.05);10mg/kg能显著增加SP、DP(P<0.01)。(2)SRI对家兔心功能的影响:与对照组比较,静脉注射SRI 2.5mg/kg对心功能各指标均无明显影响(P>0.05);5 mg/kg和10mg/kg能显著增加LVSP、±dp/dtmax(P<0.01),并能增加T值(P<0.05);SRI三个剂量对LVEDPt、-dp/dt-max均无明显影响(P>0.05)。以上参数的变化随着剂量的增加持续时间延长。结论静脉注射槐定碱5mg/kg和10mg/kg在10min内有减慢家兔心率,增加血压和心功能的作用。
Objective To studys effects of sophoridine on the hemodynamics in rabbits. Methods Thirty- two rabbits were divided randomly into three experimental groups（sophoridine 2.5,5,10mg/kg） and one control group（0.9% NaCl）.Changes of hemodynamics parameters including HR, SP,DP, LVSP, LVEDP, dp/dtmax, t- dp/dtmax, - dp/dtmax and T were recorded by cannulating femoral artery, right common carotid artery and consecutive electrocardiographic Ⅱ . Results HR reduced significantly （ P 〈 0.01 ） in sophoridine group （ 10 mg/kg, iv）, and HR reduced （ P 〈 0.05） in sophoridine group （5 mg/kg, iv） at one minute. Sophoridine 2.5 mg/kg increased significantly SP（ P 〈 0.05）. SP、DP increased greatly（ P 〈 0.01）in sophoridine groups（5 and 10mg/kg, iv）. There were no significant changes of hemodynamics in sophoridine group（2.5 mg/kg, iv）. Sophoridine 5mg/kg and 10 mg/kg increased LVSP, ± dp/dtmax（ P 〈 0.01） ,and increased T（ P 〈0.05）. There were no significant changes of LVEDP and t - dp/dtmax in all groups（ P 〉 0.05）. The more rabbits got sophoridine, the longer the changes of parameters mentioned above lasted. Conclusion Sophoridine 5 mg/kg and 10mg/kg could reduce HR and increase BP and cardiac function in rabbits in ten minutes.
出处
《宁夏医学院学报》
2007年第1期21-23,共3页
Journal of Ningxia Medical College
基金
宁夏医学院重点科研项目
