摘要
以QTc延长率为效应指标,用药代动力学-药效动力学结合模型对槐果碱、氧化槐果碱ⅳ后在兔体内的处置和效应动力学作定量分析。两药的血浓时程均符合二房室模型,两药的效应与效应室浓度之间的关系均符合S形Emax模型。两药彼此的药动学和药效学性质均有明显差异,但它们各自的药动学和药效学性质均为非剂量依赖性。
On measuring the percentage of QTc interval prolongation, the pharmacokinetic and pharmacodynamic profiles of iv sophocarpine or oxysophoearpine in rabbits were analyzed by combined pharmacokinetic and pharmacodynamic model. The plasma concentration-time profiles of the two drugs can be described by a two-compartment open model, and the relationship between effect and effect compartment concentration of both drugs can be represented by the sigmoid E_(max) model. Marked differences in pharmacokinetic and pharmacodynamic parameters between the two drugs were found, but their pharmacokinetic and pharmaeodynamic properties were dose-independent.
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1992年第3期161-164,共4页
Journal of China Pharmaceutical University
基金
国家自然科学基金
关键词
槐果碱
氧化槐果碱
药代动力学
Sophocarpine
Oxysophocarpine
Pharmacokinetics
Pharmacodynamics
Pharma-cokinetic-pharmacodynamic model
