摘要
目的:对槐定碱中主要微量杂质分离和鉴定。方法:采用柱层析法从槐定碱粗品中分离得到未知杂质,通过HPLC、IR、单晶X-射线衍射法分析鉴定其结构。结果:确证未知杂质为一对差向异构体,即槐定醇碱和异槐定醇碱,以1∶1比例形成共晶化合物。结论:槐定醇碱和异槐定醇碱的结构为首次报道。
Objection：To separate and identify the primary impurities in sophoridine.Methods：Using column chromatography method to separate the unknown impurities from the crude sophoridine,then analysing and identifing its structure through HPLC,IR,SXRD.Results：The unknown impurities were identified to be a pair of epimerides,with 1∶1 as the eutectic crystal form.Conclusion：The structure of sophoridinol and isosophoridinol is reported for the first time.
出处
《药物分析杂志》
CAS
CSCD
北大核心
2009年第4期631-632,共2页
Chinese Journal of Pharmaceutical Analysis
基金
“九五”国家科技攻关计划“新药研究与产业化开发”(1035工程)项目“槐定碱抗癌研究”专题(96-901-01-48)
关键词
槐定醇碱
异槐定醇碱
结构
单晶X-射线衍射法
sophoridinol
isosophoridinol
structure
X-ray diffraction of single crystal
