摘要
目的:探讨以土茯苓为主药的中药复方的排铅作用及对小鼠肝组织氧化损伤的保护作用。方法:采用腹腔注射醋酸铅的方法建立铅中毒模型。测定各组小鼠全血及脑、肝脏、肾脏和股骨中铅、锌、铜的含量,并检测肝脏的脂质过氧化水平。结果:中药复方对铅中毒小鼠体质量增长和脏器指数基本无影响。给予中药复方后,铅中毒小鼠血铅、脑铅、肝铅、肾铅和骨铅的含量分别下降了74%、48%、56%、51%和44%,但对体内锌、铜含量影响不显著。中药复方可使铅中毒小鼠肝脏中MDA含量下降31%,同时使GSH含量及GSH-Px、SOD活性分别增高63%、76%和66%。结论:以土茯苓为主药的中药复方不仅具有良好的排铅效果,还能有效拮抗铅中毒小鼠肝组织的氧化损伤。
Objective：To investigate the influence of traditional Chinese herbal formula with Smilax glabra on lead expelling and oxidative damage in lead-poisoned mice. Methods：Mice were received intraperitoneal injections of lead acetate to establish lead-poi- soned models. The concentration of lead, zinc and copper in blood, brain,liver, kidney and bone were determined. The lipid peroxida- tion of liver was systematically evaluated. Results：The traditional Chinese herbal formula had no influence on body weight and organ weight/body weight ratio of lead-poisoned mice. The traditional Chinese herbal formula might significantly reduce the concentration of lead in blood,rain,liver,kidney and bone,and the rate were 74 % ,48 % ,56 % ,51% and 44 % ,but had no influence on zinc＇ s and copper＇ s concentration. The decreasing rate of MDA levels in liver by the traditional Chinese herbal formula was 31%. In addition, the increase rate of GSH levels and the activities of GSH-Px and SOD in liver by traditional Chinese herbal formula were 63 % ,76 % and 66 % ,respectively. Conclusions ：The traditional Chinese herbal formula with Smilax glabra can significantly advance the excretion of lead and protect liver against oxidative damage induced by lead.
出处
《中药材》
CAS
CSCD
北大核心
2009年第3期404-406,共3页
Journal of Chinese Medicinal Materials
基金
浙江省自然科学基金(Y207783)
浙江省中医药优秀青年人才研究计划(2005Y006)
关键词
土茯苓
中药复方
铅中毒
氧化损伤
Smilax glabra
Traditional Chinese herbal formula
Lead poisoning
Oxidative damage
