摘要
目的 以大鼠为模型 ,观察饲料中添加不同铁 (1 0、5 0和 2 5 0mg kg)和锌 (1 0、4 0和 2 0 0mg kg)水平对低剂量铅 (0和 2 0 0mg kg)毒性的拮抗作用。方法 断乳一周Wistar雄性大鼠按体重随机被分成 1 1组 ,每组 1 0只。其中 1 0组饲以不同铁、锌和铅水平的饲料 ,另设 1组为未染铅正常对照 ,饲以基础正常饲料 ,1 2周后处死大鼠测定股骨生长发育有关指标。结果 研究发现 ,铅污染抑制大鼠骨骼的生长发育 ,能降低骨骼中矿物质含量和骨密度 ,补充铁锌后能改善大鼠股骨的重量和长度 ,增加股骨矿物质含量和骨密度 ,同时会增加骨铅含量。
Objective The purpose of this paper was to explore the effect of iron and zinc in diet on development of bone in growing rats exposed to lead and observed the change of bone mineral content (BMC) and bone mineral density(BMD). Methods The growing rats were fed with diet added with different levels of iron, zinc and lead for 12 weeks. Results Long\|term exposure to lead may inhibit the development of bone and reduce BMC and BMD, it can be improved the weight and length of bone and increased BMC and BMD following the increased in iron and zinc levels in the diets, but the lead level of bone increases. Conclusion Supplementary suitable iron or/and zinc could improve the BMC and BMD, the mechanism of iron and zinc in diets on bone exposed to lead should be further research.
出处
《卫生研究》
CAS
CSCD
北大核心
2004年第4期461-463,共3页
Journal of Hygiene Research
关键词
铁
锌
铅
骨矿物质含量
骨密度
iron, zinc, lead, bone mineral content(BMC), bone mineral density(BMD)
