摘要
目的探讨上皮细胞黏附分子(Ep-CAM)在食管鳞状细胞癌组织中表达的临床意义。方法应用免疫组织化学方法检测70例食管正常黏膜、癌组织和72枚区域淋巴结内 Ep-CAM 的表达情况。结果在正常食管组织中,Ep-CAM 未见阳性表达;但在食管癌组织中表达阳性率为94.3%;其表达强度与食管癌的病变长度、浸润深度无明显相关,但与肿瘤分化程度、淋巴结是否转移明显相关(P<0.001);Ep-CAM 表达强度与患者术后3年生存率呈明显负相关(P<0.001)。结论 Ep-CAM 在食管癌组织中特异性高表达,可作为食管癌诊断、预后判断及治疗的有用指标。
Objective To evaluate the clinical significance of epithelial cellular adhesion molecule (Ep-CAM)expression in esophageal squamous cell carcinoma(SCC).Methods The Ep-CAM expression was immunohistochemically investigated in 70 normal esophageal mucosas,SCCs and 72 lymph nodes.Results Ep-CAM expression was observed in 94.3% of the tumors,but no expression in the normal mucosa.The Ep- CAM expression was not significantly different between different tumor scales and tumors invading depths,its expression level was relevant with the tumors differentiation and lymph node metastases(P<0.001).The Ep- CAM expression conferred a significantly decreased 3-year survival rate after operation(P<0.001).Conclu- sion Ep-CAM was specificly expressed in esophageal SCC,it may be an attractive molecule for targeted therapy,diagnosis of esophageal SCC.
出处
《肿瘤研究与临床》
CAS
2007年第10期665-667,共3页
Cancer Research and Clinic
基金
河北省科技厅指导计划项目(062761197)
关键词
食管肿瘤
上皮细胞黏附分子
免疫组织化学
Esophageal neoplasms
Epithelial cellular adhesion molecule
Immunohistochem-istry
