摘要
目的探讨上皮细胞黏附分子(Ep-CAM)在食管癌组织中的表达的临床意义。方法采用免疫组织化学法分别检测食管癌黏膜组织(60例)、不典型增生的组织(35例)及正常食管黏膜组织(35例)中Ep-CAM的表达水平。结果 Ep-CAM在正常食管黏膜组织中无阳性表达,增生黏膜组织和癌组织中阳性表达率为分别为28.57%和90.00%,组间比较差异具有统计学意义(P<0.05);其中,Ep-CAM的表达与肿瘤分化程度、淋巴是否转移及3年生存率有显著相关性(P<0.01或P<0.05)。结论 Ep-CAM在食管癌组织中特异性表达增高,具有作为食管癌病变诊断、预后判断及治疗指标的潜在价值。
Objective To explore the clinical significance of epithelial cellular adhesion molecule （Ep-CAM） expression in esophageal carcinoma. Methods Ep-CAM expression of in 60 cases of esophageal carcinoma,35 cases of atypical hyperplasia and 35 cases of normal esophageal mu- cosa was respectively examined by irnmunohistochemistry. Results Ep-CAM expression were ob- served with positive in 28.75 % of atypical hyperplasia and 90.00 % of esophageal carcinoma, but with no positive expression in normal esophageal mucosa. The Ep-CAM expression with positive were significantly differently between degrees of tumor differentiation（P 〈 0.01）, lymphatic metastasis and 3-year survival（P〈0.05）. Conclusion The increase of Ep-CAM expression, as a specific index, may has the potential for esophageal cancer diagnosis and prognosis.
出处
《实用临床医药杂志》
CAS
2014年第15期32-34,共3页
Journal of Clinical Medicine in Practice
基金
中国高校医学期刊临床专项资金(11321632)
关键词
上皮细胞黏附分子
食管癌
肿瘤
分化程度
生存期
epithelial cellular adhesion molecule
esophageal carcinoma
tumor
differentiation
survival
