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甘露醇治疗脑出血的药理学机制和临床应用 被引量:14

Pharmacological mechanisms and clinical application of mannitol in intracerebral hemorrhage
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摘要 脑出血急性期的重要治疗措施之一是积极治疗脑水肿,降低颅内压。甘露醇为临床应用最广泛的渗透性脱水药,主要有降低颅内压、减轻脑水肿、预防脑疝形成的作用。此外,甘露醇能清除氧自由基、保护脑细胞,对于降低脑出血病死率具有极其重要的意义。 One of the important therapeutic measures in the acute stage of cerebral hemorrhage is to treat cerebral edema and lower intracranial pressure. Mannitol, an osmotic dehydrant, is most widely used in clinical practice. Its major effects include the reduction of intracranial pressure and cerebral edema and prevention of cerebral herniation. Besides, rnannitol scavenges oxygen free radicals and protects brain cells. So it has extremely important significance in reducing the mortality of intracerebral hemorrhage.
出处 《国际脑血管病杂志》 北大核心 2009年第2期115-117,共3页 International Journal of Cerebrovascular Diseases
关键词 甘露醇 脑出血 药理学过程 临床应用 mannitol intracerebral hemorrhage pharmacological processes clinical application
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