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恶性肿瘤患者外周血CD_4^+CD_(25)^+调节性T细胞的检测及其临床意义 被引量：19

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摘要 目的探讨恶性肿瘤患者外周血CD4+CD25+调节性T(Tr)细胞比例变化的特点及其临床意义。方法采用流式细胞术检测110例恶性肿瘤患者和35例健康者(对照组)外周血中CD4+CD25+Tr细胞比例。结果恶性肿瘤患者CD4+CD25+Tr细胞比例明显高于对照组(<0.01)。随疾病进展恶性肿瘤患者外周血CD4+CD25+Tr细胞比例升高[Ⅰ+Ⅱ期为(14.11±3.83)%,Ⅲ期为(20.54±4.25)%,Ⅳ期为(24.69±3.64)%],差异有统计学意义(<0.01)。结论恶性肿瘤患者外周血CD4+CD25+Tr细胞水平的升高,与恶性肿瘤免疫功能低下及肿瘤的发生发展密切相关。去除这群细胞可有效诱导肿瘤免疫,为肿瘤治疗提供一种新的思路。
作者 邵明海 王建华 丁维军 胡炜 王碧云
机构地区 温州医学院附属台州医院
出处 《现代实用医学》 2009年第2期142-143,共2页 Modern Practical Medicine
关键词 肿瘤 免疫组织化学
分类号 R730.45 [医药卫生—肿瘤]
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参考文献9

  • 1Itoh M, Takahashi T, Sakaguchi, et al. Thymus and autoimmunity: production of CD4^+ CD25^+ naturally anergic and suppressive T cells as a key function of the thymus in mainraining immunologic self-tolerance[J]. J Immunol,1999,162(9):5317-5326. 被引量：1
  • 2Seo N, Hayakawa S, Taldgawa M, et al. Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4^+ T regulatory cells and systemic collapse of antitumour immunity[J]. Immunology,2001,103 (4): 449 - 457. 被引量：1
  • 3Horwitz DA, Zheng SG, Gray JD. The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4^+CD25^+ and CD8 regulatory T cellsubsets [J]. J Leukoc Bioi,2003,74(4): 471-478. 被引量：1
  • 4Bopp T, Palmetshofer A, Settling E, et al. NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4^+ T lymphocytes by CD4^+CD25^+ regulatory T cells [J]. J Exp Med,2005,201(2): 181 - 187. 被引量：1
  • 5Baecher-Allan C, Brown J A, Freeman G J, et al. CD4^+high CD25^+ regulatory cells in human peripheral blood[J].J Immunol,2001,167(3): 1245-1253 被引量：1
  • 6Sasada T, Kimura M, Yoshida Y, et al. CD4^+CD25^+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression [J] .Cancer ,2003,98 (5): 1089-1099. 被引量：1
  • 7刘莉,丁乾,曹如波,王晶,姚军霞,黄士昂.恶性肿瘤患者外周血CD4^+ CD25^+调节T细胞的检测及其临床意义[J].临床肿瘤学杂志,2005,10(4):342-345. 被引量：16
  • 8Tanaka H, Tanaka J, Kjaergaard J, et al. Depletion of CD4^+CD25^+ regulatory cells aug- ments the generation of specific immune T cells in tumor-draining lymph nodes[J]. J Immunother,2002,25(3): 207 - 217. 被引量：1
  • 9Nagai H, Horikawa T, Hara I, et al. In vivo elimination of CD25^+ regulatory T cellleads to tumor rejection of B 16F 10 melanoma, when combined with interleukin-12 gene transfer [J]. Exp Dermatol,2004,13(10):613 - 620. 被引量：1

二级参考文献8

  • 1Itoh M, Takahashi T, Sakaguchi, et al. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance[J]. J Immunol,1999,162(9):5317-5326. 被引量：1
  • 2Seo N, Hayakawa S, Takigawa M, et al. Interleukin-10 expressed at early tumour sites induces subsequent generation of CD4(+) T-regulatory cells and systemic collapse of antitumour immunity[J]. Immunology, 2001,103(4):449-457. 被引量：1
  • 3Rosenberg SA. Progress in human tumour immunology and immunotherapy[J]. Nature, 2001,411:380-384. 被引量：1
  • 4Seitz J, Bruck J, Lenz J, et al. Deletion of CD4+ CD25+ T cells and treatment with tyrosinase-related protein2-transduced dendritic cells enhance the interferon alpha-induced, CD8+ T-cell-dependent immune defense of B16 melonoma[J]. Cancer Res, 2001,61:8643-8646. 被引量：1
  • 5Sutmuller RP, van Duivenvoorde LM, van Elsas A, et al. Synergism of cytotoxic T lymphocyte-associated antigen 4 blockade and depletion of CD25(+) regulatory T cells in antitumor therapy reveals alternative pathways for suppression of autoreactive cytotoxic T lymphocyte responses[J]. J Exp Med,2001,194(6):823-832. 被引量：1
  • 6Tanaka H, Tanaka J, Kjaergaard J, et al. Depletion of CD4+ CD25+ regulatory cells augments the generation of specific immune T cells in tumor-draining lymph nodes[J]. J Immunother,2002,25(3):207-217. 被引量：1
  • 7Wolf AM, Wolf D, Steurer M, et al. Increase of regulatory T cells in the peripheral blood of cancer patients[J]. Clin Cancer Res,2003,9(2):606-612. 被引量：1
  • 8Sasada T, Kimura M, Yoshida Y, et al. CD4+CD25+ regulatory T cells in patients with gastrointestinal malignancies: possible involvement of regulatory T cells in disease progression[J]. Cancer, 2003,98(5):1089-1099. 被引量：1

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二级引证文献156

现代实用医学
2009年 第2期

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