摘要
目的研究慢性淋巴细胞白血病(CLL)患者血淋巴细胞亚群与临床分期的关系。方法采用流式细胞仪检测患者及正常成人血中淋巴细胞亚群比例、CD4/CD8比值。结果与正常成人比较,Ⅰ～Ⅱ期CLL患者血中总T、T辅助细胞、CD4/CD8略降低,T抑制细胞略增高(P>0.05);而NK细胞略增高(P>0.05)。Ⅲ期CLL总T、T辅助细胞及CD4/CD8明显下降(P<0.05),NK细胞明显降低(P<0.05)。与Ⅰ～Ⅱ期比较,Ⅲ期患者的总T、T辅助细胞、CD4/CD8和NK细胞明显下降(P<0.05)。结论淋巴细胞亚群的分析有助于CLL病情的判断。
Objective To study the relation of lymphocyte subsets and clinical different times in chronic lymphocytic leukemia. Methods To determine the CD3^+ ,CD4^+, CD8^+, CD4^+/CD8^+, NK cell in peripheral blood of CLL and healthy adult by flowcytometer(FCM). Results The levels of CD3^+, CD4^+, CD4^+/CD8^+ were depressed and CD8^+, NK cell were increased in Ⅰ～Ⅱstage of CLL as compared with healthy controls ( p > 0. 05) . The levels of CD3^+, CD4^+, CD4^+/CD8^+ were depressed and NK cell were increased more significantly in Ⅲ stage of CLL as compared with healthy controls( P< 0. 05). The levels of CD3^+, CD4^+, CD4^+/CD8^+ were depressed and NK cell were increased more significantly in Ⅲ stage of CLL as compared with Ⅰ～Ⅱstage of CLL( P< 0. 05).Conclusion The analysis of lymphocyte subsets is helpful to diagnose the different stage in chronic lymphocytic leukemia.
出处
《现代肿瘤医学》
CAS
2005年第4期485-486,共2页
Journal of Modern Oncology
