摘要
[目的]研究转化生长因子-β1（transforming growth factor-β1，TGF-β1）基因＋869T／C多态性与高血压心房颤动发生的关系，探讨TGF-β1基因＋869T／C基因型对高血压心房颤动发生的影响。[方法]采用序列特异性引物聚合酶链反应（PCR-SSP），检测99例高血压患者（其中47例伴心房颤动）及49名对照组TGF-β1基因＋869T／C。[结果]在高血压心房颤动组中＋869T／C位点的CC基因型频率高于高血压无心房颤动组及对照组，差异有统计学意义（P〈0．05），高血压心房颤动组＋869C等位基因频率高于高血压无心房颤动组及对照组，差异有统计学意义（P〈0．05），与高血压无心房颤动组比较，携带C等位基因的个体患心房颤动的相对风险度（0R）为2．044（95％CI：1．157～3．612）。[结论]TGF-β＋869CC基因型是高血压心房颤动的易感基因型；C等位基因可能是高血压心房颤动发病的遗传易感基因。
[Objective]To explore the association of genetic polymorphisms of transforming growth factor （TGF-β1） in patients with atrial fibrillation and essential hypertension. [Methods] The polymorphisms of TGF-β1 d-869T/ C gene were analyzed by sequence specific primers-polymerase chain reaction（PCR-SSP）methods in 99 patients with essential hypertension（including 47 patients with atrial fibrillation）and 49 healthy controls. [Results] The frequencies of TGF-β1＋869CC genotypes for the essential hypertension with atrial fibrillation group were significantly higher than those of the essential hypertension without atrial fibrillation group and the control group. The differences had statistical significance（ P 〈0.05）, ＋869C alleles for the essential hypertension with atrial fibrillation were signifi- cantly higher than those of the essential hypertension without atrial fibrillation group and the control group. The differences had statistical significance（ P 〈0.05）. The relative risk suffered from essential hypertension with atrial fibrillation of C allele was 2.044 times of the T allele（OR=2. 044,95%CI：1. 157-3. 612）. [Conclusion] TGF-β1- 869CC genotype may be a susceptible factor to the essential hypertension with atrial fibrillation, and C allele may be a risk factor for essential hypertension with atrial fibrillation.
出处
《医学临床研究》
CAS
2009年第2期211-213,共3页
Journal of Clinical Research
基金
广东省科技计划项目（2008B030301142）
