摘要
目的探讨手术加药物综合治疗对变应性鼻炎并鼻息肉病人血清中特异性IgE(SIgE)水平的影响。方法应用酶联免疫吸附试验(ELISA)双抗体夹心法,对30例变应性鼻炎并鼻息肉病人应用手术加药物综合治疗,分别于术前、术后进行血清粉尘螨、屋尘螨SIgE检测,并与25例健康志愿者(对照组)进行比较。结果变应性鼻炎并鼻息肉病人治疗前血清中粉尘螨、屋尘螨SIgE含量高于对照组,差异有显著性(t=20.571、18.710,P<0.01);治疗后1、3、5周病人血清中粉尘螨、屋尘螨SIgE含量较治疗前降低,差异有显著意义(F=4.002、3.996,q=23.423～68.983,P<0.01);并且随时间的延长呈递减趋势(q=16.595～40.476,P<0.01)。结论变应性鼻炎并鼻息肉病人体内存在高浓度的SIgE,手术加药物综合治疗可使其血清中SIgE含量降低。
Objective To investigate the influence of surgery plus drug therapy on serum specific IgE （SIgE） levels in patients with allergic rhinitis associated nasal polyp （ARANP）. Methods Serum of 30 ARANP patients was detected for house dust mite and dermatophagoides farinae SIgE with enzyme linked immuneosorbent assay （ELISA） before and after treatment. The result was compared with that of 25 healthy volunteers. Results The serum SIgE in ARANP patients, before treatment, was higher than that in normal control （t=20. 571,18. 710;P〈0.01）. After treatment, the serum SIgE decreased and reached statistical difference compared with before treatment （F=4. 002,3. 996;q= 23. 423--68. 983;P〈0.01）, and decreasing along with the prolong of therapy （q=16. 595--40. 476,P〈0.01）. Conclusion High level SIgE exists in patients with ARANP. Surgery plus drug therapy can decline the serum content of SIgE of the patients.
出处
《齐鲁医学杂志》
2009年第1期45-46,48,共3页
Medical Journal of Qilu
关键词
鼻炎
变应性
常年性
鼻息肉
免疫球蛋白E
Rhinitis, allergic, perennial
Nasal polyps Immunoglobulin E
