摘要
转录因子7样2（TCF7L2）基因是2型糖尿病最重要的易感基因之一，其基因变异体与2型糖尿病有强相关性，是目前2型糖尿病多因子遗传学领域中最引人注目的基因之一。这一结果在许多人种中都得以证实，而在我国关于该基因的研究刚刚起步。TCF7L2基因位于染色体10q25，共编码619个氨基酸，其产物是Wnt信号通路中一种转录因子。该因子通过对胰高血糖素样肽-1（GLP-1）水平调节，在糖代谢中起重要作用。另外，该信号通路与胰腺和胰岛的正常发育密切相关。
By far the most spectacular development in the field of multifactorial type 2 diabetes genetics has been the identification of transcription factor 7-like 2 （TCF7L2）. It is one of the most important type 2 diabetes-susceptibility gene. Common variants in the gene that encodes TCF7L2 have been strongly associated with type 2 diabetes. The result has been proved in various ethnic groups, but the study of TCF7L2 is just started in China. The TCF7L2 gene is on chromosome 10q25 and encoded 619 amino acids. It is a transcription factor involved in the Wnt signaling pathway. TCF7L2 plays an important role in glucose metabolism by regulating the production level of glucagon-like peptide-1 （ GLP-1 ）. In addition, tightly regulated Wnt signaling is required for the normal development of the pancreas and islets during embryonic growth.
出处
《国际内分泌代谢杂志》
2009年第1期26-28,共3页
International Journal of Endocrinology and Metabolism
关键词
单核苷酸多态性
转录因子7样2
2型糖尿病
Single nucleotide polymorphisms
Transcription factor 7-like 2
Type 2 diabetes meUitus
