摘要
目的观察抗CD105单克隆抗体对大肠癌生长的影响。方法建立裸小鼠人类大肠癌细胞动物模型，将44只裸小鼠随机分为2组，分别为抗体组和生理盐水组，抗体组在接种大肠癌细胞的同时，经腹腔注射抗CD105单克隆抗体，生理盐水组在接种大肠癌细胞的同时，经腹腔注射生理盐水，计算肿瘤体积和抑瘤率，并做组织病理学检查。结果抗CD105单克隆抗体可抑制人类大肠癌细胞株LoVo的生长，最高抑瘤率为71．88％，抗体组与生理盐水组比较肿瘤明显受抑制（P〈0．05）。结论抗CD105单克隆抗体对人类大肠癌细胞株LoVo的生长有明显抑制作用。
Objective To observe the inhibitory effect of anti-CD105 monoclonal antibody on tumor growth of large intestine carcinoma. Methods We established an animal model of human large intestine carcinoma in nude mice, and inhibitory effects of anti-CD105 monoclonal antibody were tested. Forty-four nude mice with human large intestine carcinoma were randomly divided into 2 groups：In antibody group the mice were treated with monoclonal antibody, and in normal saline group the mice were given normal saline. The tumor volume and the tumor growth inhibition rate were calculated, and the tumor was his- topathlogically examined. Results The growth of human large intestine carcinoma cell line LoVo cells in antibody group was dramatically inhibited. As compared with the normal saline group, growth of the tumor was significantly reduced in size in the mice treated with anti-CD105 monoclonal antibody, with an inhibition rate of 71.88% （P 〈 0.05）. Conclusion The anti-CD105 monoclonal antibody had a significant inhibitory effect on the growth of large intestine carcinoma in mice.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2009年第2期165-166,共2页
Chinese Journal of Experimental Surgery
基金
基金项目：广东省医学科研基金资助项目（A2003563）
关键词
大肠癌
单克隆抗体
CD105
Large intestine carcinoma
Monoclonal antibody
CI）105
