摘要
目的 探讨食管癌患者血清可溶性Endoglin水平的变化及其临床意义.方法 酶联免疫吸附试验法（E LISA）检测59例食管癌患者以及33例正常人血清可溶性Endoglin水平,并观察41例食管癌患者手术前后血清可溶性Endoglin水平变化.结果 食管癌患者血清可溶性Endoglin水平[（5.11±0.79） μg/L]明显高于正常对照组[（3.53 ±0.15） μg/L,P＜0.01],随着疾病的进展,血清可溶性Endoglin水平逐渐升高,血清可溶性Endoglin水平与临床分期、细胞分化程度明显相关,与性别、年龄无明显相关,Ⅳ期食管癌患者血清可溶性Endoglin水平[（6.23±0.15）μg/L]明显高于Ⅲ期[（5.52 ±0.17） μg/L,P＜0.01],Ⅲ期明显高于Ⅱ期[（4.72±0.15） μg/L,P＜0.01],Ⅱ期明显高于Ⅰ期[（4.11 ±0.16） μg/L,P＜0.01],Ⅰ期明显高于正常对照组（P＜0.01）;食管低分化鳞癌患者血清Endoglin水平[（5.65 ±0.65） μg/L]显著高于食管中分化鳞癌患者[（5.10 ±0.80） μg/L]及食管高分化鳞癌患者[（4.65±0.58） μg/L,P＜0.05];手术后食管癌患者血清可溶性Endoglin水平[（4.30 ±0.52） μg/L]较手术前[（4.70±0.54）μg/L]明显降低（P＜0.01）.结论 测定血清可溶性Endoglin表达水平有助于食管癌患者观察病情、监测疗效和判断预后.
Objective To analyze the changes of serum soluble endoglin in patients with esophageal carcinoma and its clinical value.Methods Enzyme linked immunosorbent assay （ELISA） was used to detect serum soluble endoglin level in 59 cases of esophageal carcinoma and 33 cases of normal controls.The serum soluble endoglin level was compared in 41 patients with esophageal carcinoma pre-and post-operation.Results The serum soluble endoglin level was elevated in all subgroups of patients with esophageal carcinoma [（5.11 ±0.79） μg/L] compared to the controls [（3.53 ±0.15） μg/L] （P 〈0.01）.Serum soluble endoglin was correlated with clinical stage and histological grade,but not with sex and age.The serum soluble endoglin level in stage Ⅳ [（6.23 ± 0.15） μg/L] was higher than that in stage Ⅲ [（5.52 ± 0.17） μg/L,P 〈 0.01],that in stage Ⅲ higher than that in stage Ⅱ [（4.72 ± 0.15） μg/L,P 〈 0.01],that in stage Ⅱ higher than that in stage Ⅰ [（4.11 ± 0.16） μg/L] （P 〈 0.01）,and that in stage Ⅰ higher than that in normal controls （P 〈 0.01）.Serum soluble endoglin level was higher in the poorly differentiated [（5.65 ±0.65） μg/L] than that in moderately differentiated [（5.10 ±0.80） μg/L] and well differentiated [（4.65 ± 0.58） μg/L,P 〈 0.05].The serum soluble endoglin levels were remarkably reduced in patients with esophageal carcinoma after operation （P 〈 0.01）.Conclusion Detection of serum soluble endoglin may be a reference mark to observe patients＇ condition,monitor curative effect and judge prognosis of esophageal carcinoma.
出处
《中华实验外科杂志》
CAS
CSCD
北大核心
2014年第11期2587-2588,共2页
Chinese Journal of Experimental Surgery
