摘要
目的检测口腔鳞癌(oral squamous cell carcinoma,OSCC)组织中CD105的表达,并探讨CD105与口腔鳞癌临床病理特征和预后之间的相关性。方法采用免疫组化(SP)方法,用抗CD105抗体分别标记正常黏膜组织和鳞癌组织中的血管内皮细胞,测定微血管密度(MVD),并分析CD105-MVD与口腔鳞癌临床病理特征及预后的相关性。结果 CD105在病变组织中的表达与正常组织有明显差异(P<0.05);OSCC组织中,CD105-MVD高表达率与分化程度、临床分期、T分类、淋巴结转移密切相关,差异有统计学意义(P<0.05);与年龄、性别、吸烟无关(P≥0.05);CD105-MVD高表达组患者五年生存率低于CD105-MVD低表达组生存率,两者间差异有统计学意义(P<0.05)。结论 CD105与年龄、性别、吸烟与否无明显相关性;与OSCC的病理分级、临床分期、T分类、淋巴结转移有关;CD105高表达组患者预后差,可以作为OSCC预后的参考指标之一。
Objective To investigate the expression of CD105 in oral squamous cell carcinoma（OSCC） and to probe into CD105＇ s correlations with the pathological characteristics and prognosis in OSCC. Methods Immunohistochemistry was used to mark vascular endothelial cells in the normal tissue group and OSCC tissue groups by anti-CD105 antibody,to measure MVD（Microvessel Density）,and to analyze the correlations between CD105-MVD and the pathological characteristics and prognosis in OSCC. Results A positive stain of CD105 was observed in OSCC,which significantly differed from the normal tissue group（P 〈0. 05）; In the OSCC tissue group,the expression of CD105 was associated with the degree of differentiation,clinical stage,T classification and lymph node metastasis（P〈0. 05）,but not with age,sex or smoking（P≥0. 05）. Besides,the five-year survival rates of patients with high CD105-MVD were lower than that of patients with low CD105-MVD（P〈0. 05）. Conclusions CD105 has no correlation with age,sex or smoking,but has a relationship with the degree of differentiation,clinical stage,T classification,lymph node metastasis and prognosis in OSCC.Besides,the low survival rates of patients with high CD105-MVD can be referred to as an index of prognosis.
出处
《口腔医学》
CAS
2015年第4期266-269,共4页
Stomatology
基金
黑龙江省教育厅科学技术研究项目(12541499)
黑龙江省高等教育教学改革项目(JG2013010417)
