摘要
白细胞介素10（IL—10）是目前研究热门且了解较多的抗炎性因子，能发挥抗炎性反应作用。IL-10受体（IL-10R）存在于单核吞噬细胞膜上，能与IL-10结合后发挥抗炎作用，转录激活因子3（STAT3）是该过程的关键因素，通过与IL-10R上的暂时锚靠位点结合而活化。活化的STAT3激活某些控制炎症靶点转录的基因，发挥抗炎症作用。
Interleukin-10（IL-10） is the best known and studied of the anti-inflammatory cytokines and develops the potent anti-inflammatory response（AIR）. The IL-10 receptor（IL-10R） resides in the cell membrane of the mononuclear phagocyte system,which binds to IL-10 to generate anti-inflammatory effect. The signal transducer and activator of transcription 3 （STAT3）plays a critical role, which passages the dock of IL-10R to be activated. Thus STAT3 activates other genes which task is to selectively control transcription of inflammatory targets.
出处
《医学综述》
2009年第1期52-54,共3页
Medical Recapitulate
关键词
抗炎性反应
白细胞介素10
信号转导和转录激活因子3
The potent anti-inflammatory response
Interleukin-10
Signal transducer and activator of transcription 3
