摘要
目的:观察硫酸氨基葡萄糖和透明质酸钠治疗膝关节髌股关节骨关节炎的疗效及安全性。方法:86例髌股关节骨关节炎病人随机分为硫酸氨基葡萄糖组(A组)和透明质酸钠组(B组),每组43例。A组口服硫酸氨基葡萄糖胶囊每次2粒,每日3次,连续服用12周。B组关节内注射透明质酸钠2mL,1次/周,共5次。随访半年观察其临床疗效及不良反应。结果:硫酸氨基葡萄糖治疗骨关节炎总有效率为83.7%,透明质酸钠组总有效率为86%,两组病人生活质量明显提高,经比较差异无统计学意义(P>0.05)。A组和B组不良反应发生率分别为2.3%和9.3%,两组差异有统计学意义(P<0.05)。结论:硫酸氨基葡萄糖和透明质酸钠治疗膝关节髌股骨关节炎均可以改善临床症状,硫酸氨基葡萄糖不良反应较少。
Objective：To compare the therapeutic efficacy and safety of glucosamine sulfate and hyaluronate in the treatment of patellofemoral osteoarthritis. Methods： A total of 86 patients with patellofemoral osteoarthritis were selected. Then the randomized and double - blind study was conducted. The patients were assigned to two groups： 43 patients in glucosamine group taken glucosamine sulfate orally, two pills every time, ter in die, 12 weeks continuously, other 43 patients in hyalnronate group received intra -articular injection of sodium hyaluronate, once a week, five weeks continuously. The curative effects and adverse reactions were observed and followed up. Results： The effective rates of glucosamine sulfate and hyaluronate were 83.7% and 81.4% respectively. The patients＇ quality of life in two groups improved obviously. There was not significant difference between two groups. The incidences of side effects were 2.3% and 9.3% in two groups respectively, which in hyaluronate group was significantly increased. Conclusion：Glucosamine sulfate, as well as hyaluronate could improve the clinical symptoms of patellofemoral osteoarthritis, moreover, the incidence of side effects in the patients treated by glucosamine sulfate was lower.
出处
《解剖与临床》
2008年第6期418-420,共3页
Anatomy and Clinics
关键词
骨关节炎
随机对照试验
氨基葡萄糖
透明质酸钠
Osteoarthritis
Randomized controlled trials
Glucosamine
Sodium hyaluronate
