摘要
目的对进行规范治疗的妊娠梅毒患者进行梅毒血清学随访,探讨妊娠梅毒TRUST血清学转归的影响因素。方法通过对妊娠女性进行梅毒筛查,发现妊娠梅毒并进行分期,记录妊娠梅毒患者病史,规范治疗。治疗结束后对其进行至少2年的TRUST血清学随访,记录治疗结束后半年、1年和2年时TRUST状况和滴度。结果配偶TRUST阳性妊娠梅毒患者的TRUST远期(2年)阴转率高于配偶TRUST阴性患者,差异有统计学意义(P<0.01);晚期潜伏梅毒的TRUST转阴率明显低于早期梅毒,差异有统计学意义(P<0.01);不良妊娠史、发现及治疗的时间和妊娠梅毒患者的血清学转阴间可能没有关系(P>0.05);TRUST滴度≤1∶8患者转阴率明显低于滴度>1∶8患者,差异有统计学意义(P<0.01)。结论经规范的驱梅治疗后,TRUST滴度高、配偶梅毒血清学阳性、早期梅毒的妊娠梅毒患者血清TRUST相对容易转阴。
Objective To study the TRUST outcome and influencing factor in pregnant syphilis with standard treatment. Methods To screen serum TRUST in pregnant women, discovering pregnant syphilis and their disease stage, the patients were treated with standard program and recorded medical history. After treatment, the patients＇ serum TRUST were reexamined in half year, 1 year, 2 year. Results The rate of TRUST turnover of pregnant syphilis in spouse with positive TRUST was significantly higher than in spouse with negative TRUST （ P 〈 0.01 ）. The rate of TRUST turnover in early stages syphilis was significantly higher than in late latent syphilis （ P 〈 0. 01 ）. The rate of TRUST turnover could be no relationship on unhealthy pregnant history and the pregnant stage of discovery and treatment （ P 〉0. 05） ; and then TRUST turnover with TRUST titer ≥ 1 ： 8 was significantly higher than in titer 〈 1 ： 8 （ P 〈 0.01 ）. Conclusion After standard treatment, TRUST is more easy turnover in higher TRUST titer, spouse with positive TRUST, early stage in pregnant syphilis.
出处
《实用心脑肺血管病杂志》
2008年第12期1-3,共3页
Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease
基金
深圳市科技局科研立项课题(JH200507131003A)
