摘要
以邻苯二甲酸酐和丙二酸为原料，合成邻乙酰基苯甲酸，经酰氯化反应得邻乙酰基苯甲酰氯，再与不同胺类化合物反应，得到3种邻乙酰基苯甲酰胺化合物，总反应收率55．0％～61．9％。第3步最佳的工艺条件为：反应温度0℃，pH8～9，反应时间0．5h，二氧六环、水、三乙胺体系。所得化合物结构经^1H NMR，^13 CNMR，IR和MS进行表征。
o-Acetylbenzoic acid, which was prepared from phthalic anhydride and malonic acid, reacted with thionyl chloride to obtain o-acetylbenzoyl chloride. Then three o-acetylbenzamide derivatives were synthesized by o-acetylbenzoyl chloride with different amines, the overall yields were 55.0% ～ 61.9%. The optimum condition of the third step for the reaction were as follows ： temperature was 0 ℃, pH = 8 ～ 9 ,reaction time was 0.5 h ,system was 1,4-dioxane, H2O and triethylamine. These compounds were characterized by ^1H NMR,^13C NMR, IR and MS.
出处
《应用化工》
CAS
CSCD
2008年第12期1468-1471,共4页
Applied Chemical Industry
关键词
邻苯二甲酸酐
酰氯
酰胺
合成
phthalic anhydride
acyl chloride
acyl amide
synthesis
