摘要
目的探讨抗环瓜氨酸肽抗体(anti-CCP)、葡萄糖-6-磷酸-异构酶抗原(GPI)、抗角蛋白抗体(AKA)、类风湿因子(RF),四项指标联合检测在类风湿关节炎(RA)诊断中的价值。方法对78例RA、86例非RA其他风湿病患者、80名健康志愿者的anti-CCP、GPI、AKA、RF进行检测。结果78例RA患者中anti-CCP、GPI、AKA及RF的灵敏度分别为51.2%(40/78)、42.3%(33/78)、29.5%(23/78)和58.9%(46/78);特异性分别为98.2%(163/166)、98.8%(164/166)、98.2%(163/166)和81.9%(136/166)。86例非RA其他风湿病患者anti-CCP、GPI、AKA及RF的阳性率分别为2.33%(2/86)、2.33%(2/86)、3.49%(3/86)和33.7%(29/86);80名正常对照组中检测到1例抗CCP弱阳性,1例RF阳性,其余指标均为阴性。结论anti-CCP、GPI、AKA对RA诊断灵敏度不高,但均是RA的特异性诊断指标,三者与RF可相互补充,适当的联合检测有助于提高诊断的特异性。
Objective To evaluate the clinical value of combined detection of anti-cyclic citrullinated peptide antibody ,glucose-6-phosphate isomerase,anti-keratin antibody and rheumatoid factor for early diagnosis of rheumatoid arthritis. Methods The levels of anti-CCP,GPLAKA,RF in 78 patients with established RA,86 patients with other rheumatic diseases and 80 normal controls were determined. Results The sensitivity of anti-CCP,GPI,AKA and RF in the diagnosing of RA were 51.2%（40/78）, 42.3%（33/78）, 29.5%（23/78） and 58.9% （46/78）,respectively;the specificity were 98.2% （163/166）, 98.8%（164/166）, 98.2%（163/166） and 81.9% （136/166）,respectively.The positive rates of anti-CCP,GPI, AKA and RF in other rheumatic diseases patients were 2.33%（2/86）, 2.33%（2/86）, 3.49%（3/86） and 33.7%（29/86）.There was one faintly positive result of anti-CCP and one positive result of RF in 80 normal controls. Conclusion Though the sensitivity of anti-CCP, GPI, AKA are not high in diagnosis of RA but they are still thespecific indicators and combined detection of these indicators can enhance the specificity in diagtnosis of RA.
出处
《中国热带医学》
CAS
2009年第1期72-73,共2页
China Tropical Medicine
