摘要
目的:观察手腕部韵律操联合甲氨蝶呤、来氟米特治疗类风湿关节炎的临床疗效。方法:将80例类风湿关节炎患者随机分为治疗组和对照组,每组40例。对照组采用常规抗风湿治疗(甲氨蝶呤、来氟米特),治疗组在对照组治疗基础上辅以手腕部关节韵律操的运动疗法。2组均以8周为1个疗程。观察2组临床疗效,以及治疗前后关节疼痛、关节肿胀、关节屈伸不利和晨僵等中医临床症状积分,类风湿因子(RF)、红细胞沉降率(ESR)、C-反应蛋白(CRP)等实验室指标,并计算DAS28评分。结果:治疗组临床控制10例,显效15例,有效12例,无效3例,总有效率为92.50%;对照组临床控制10例,显效15例,有效7例,无效8例,总有效率为80.00%。2组比较,差异有统计学意义(P<0.05)。治疗后,2组关节疼痛、关节肿胀、关节屈伸不利、晨僵评分较治疗前均显著下降(P<0.01),且治疗组低于对照组(P<0.01)。2组RF、ESR、CRP和DAS28评分较治疗前均有改善(P<0.01),且治疗组DAS28评分优于对照组(P<0.05)。结论:手腕部韵律操联合甲氨蝶呤、来氟米特能有效改善患者关节肿胀、疼痛,缓解晨僵现象,明显降低中医临床症状积分及DAS28评分,提高临床疗效。
Objective:To observe the clinical effect of wrist rhythmic gymnastics combined with methotrexate and leflunomide in the treatment of rheumatoid arthritis.Methods:Eighty patients with rheumatoid arthritis were randomly divided into a treatment group and a control group,40 cases in each group.The control group was treated with routine anti-rheumatism therapy(methotrexate,leflunomide),while the treatment group was treated with wrist rhythmic gymnastics based on the treatment for the control group.Both groups were treated for 8 weeks.The clinical effects,the scores of clinical symptoms(including joint pain,joint swelling,adverse joint flexion and extension,morning stiffness),laboratory indicators(rheumatoid factor(RF),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP)before and after treatment of the two groups were observed,and the DAS28 scores were calculated.Results:In the treatment group,10 cases were clinically controlled,15 cases were markedly effective,12 cases were effective,3 cases were ineffective,and the total effective rate was 92.50%.In the control group,10 cases were clinically controlled,15 cases were markedly effective, 7 cases were effective and 8 cases were ineffective,and the total effective rate was 80.00%.There was a significant difference between the two groups (P < 0.05).After treatment,the scores of joint pain,joint swelling,adverse joint flexion and extension,morning stiffness in the two groups were significantly lower than those before treatment(P < 0.01),and the scores in the treatment group were lower than those in the control group(P < 0.01).The scores of RF,ESR,CRP and DAS28 in the two groups were improved compared with those before treatment(P < 0.01),and the scores of DAS28 in the treatment group were better than those in the control group(P < 0.05).Conclusion:Wrist rhythmic gymnastics combined with methotrexate and leflunomide can effectively improve joint swelling and pain,relieve morning stiffness,significantly reduce clinical symptoms score and DAS28 score,and improve clin
作者
余文景
梁翼
李敏
沙湖
许静
夏琴
YU Wen-jing;LIANG Yi;LI Min;SHA Hu;XU Jing;XIA Qin
出处
《风湿病与关节炎》
2019年第9期19-21,45,共4页
Rheumatism and Arthritis
基金
四川省骨科医院科研项目(201513)
关键词
关节炎
类风湿
手腕部韵律操
甲氨蝶呤
来氟米特
临床疗效
arthritis,rheumatoid
wrist rhythm gymnastics
methotrexate
leflunomide
clinical efficacy
