摘要
在建立门诊肝癌专病病历的基础上,收集经凌昌全教授诊治的552例肝癌患者合计2020张门诊有效处方,使用频数法总结凌教授的临床常用药物及其性味归经。运用logistic回归方法分析其辨证用药特点,聚类分析归纳其临床常用对药,结合专家体会对数据结果进行分析。凌教授治疗肝癌临床常用药物以健脾开胃、解毒抗癌和活血化瘀类为主,药性多平、凉,药味主以甘、苦、辛。气虚多选用黄芪、白术、太子参;血虚多用鸡血藤、大枣;阴虚多选用山茱萸、麦门冬;水湿多用藿香、车前子、茯苓皮;实热多选用山栀、黄芩;血瘀多选用桃仁、赤芍;气滞多用郁金、八月札、柴胡。聚类分析共总结出19对临床常用对药。
On the basis of outpatients＇ medical records concerning primary liver cancer （PLC）, data of 552 patients （with 2 020 effective prescriptions） from the Outpatient Department of Changhai Hospital treated by Professor Ling Changquan were collected. The nature, flavor and meridian distribution of the herbs used in the prescriptions were summarized by frequency method, and the features of the herbs used according to syndrome differentiation were analyzed by logistic regression. The couple herbs used were analyzed by cluster analysis. All the data were analyzed in combination with the experience of the specialist. It showed that most of the frequently used herbs were herbs for invigorating the spleen to promote appetite, removing toxic materials to inhibit tumor growth, and activating blood circulation to dissipate blood stasis. These herbs are mostly of plain or cool nature, and mainly of sweet, bitter, or acrid taste. It also showed that the most frequently used herbs for qi deficiency were Astragalus membranaceus, Atractylodes macrocephala, and Pseudostellariae; Caulis Spatholobi and Chinese jujube for blood asthenia; Fructus Corni and Ophiopogon japonicus for yin deficiency; Agastache rugosa, Semen Plantaginis and Poria for water-dampness; cape jasmine fruit and baikal skullcap root for heat excess; peach seed and Radix Paeoniae Rubra for blood stasis; Curcuma wenyujin, Akebia trifoliata and Bupleurum chinense for qi stagnation. A total of 19 pairs of couple herbs were summarized by the cluster analysis.
出处
《中西医结合学报》
CAS
2008年第12期1221-1225,共5页
Journal of Chinese Integrative Medicine
基金
上海市科学技术委员会基础研究基金资助项目(No.05JC14044)
上海市教育委员E-研究院建设计划资助项目(No.E03008)
关键词
凌昌全
肝癌
数学分析
统计
名医经验
Ling Changquan
liver cancer
data analysis, statistical
famous doctor＇s experience
