摘要
目的:探讨方剂与证候的对应与临床的紧密关系,阐明中医方剂疗效的基础在于临床辨证的准确。方法:采用前瞻性研究的方法,进行随机双盲对照试验研究,选择2级高血压的主要证候——阴虚阳亢证患者92例,随机分为方证对应组(Ⅰ组)、方证不对应组(Ⅱ组)及安慰剂组(Ⅲ组),分别给予外观及包装相同,但内容不同的中药"平压合剂"口服,在用药前后观察其临床疗效和客观指标的改善情况,并进行统计学处理。结果:治疗4周后,使用证候疗效判定标准判定疗效,Ⅰ组有效率:96.88%,Ⅱ组有效率:56.67%,Ⅲ组有效率:6.67%。Ⅰ组与Ⅱ组、Ⅲ组在各时段1次血压,治疗后3d三个时段平均血压,治疗后24h动态血压降压疗效上均有统计学差异(P<0.05)。3组治疗前后血常规、肝肾功能指标无统计学意义(P<0.05)。结论:中医传统治疗高血压病阴虚阳亢证的代表方剂是有效的。
Objective： To discuss the close relationship between clinical practice and the correspondence of prescriptionssyndrome, and to elucidate that the curative effect of prescriptions of TCM bases on the accurate syndrome differentiation. Methods： Perspective study was used to carry out a double-blind randomized controlled trial. 92 cases of grade- Ⅱ hypertension with syndrome of hyperactivity of yang due to yin deficiency were divided into correspondence of prescription-syndrome group （group-Ⅰ）, non-correspondence of prescription-syndrome group （group-Ⅱ） and placebo group （group-Ⅲ） at random. ＂Blood Pressure Pacification Mixture＂ with the same external packing but different Chinese medicines was given to the groups respectively. Clinical curative effect and the improvement condition of objective indexes were observed before and after the treatment. Results： After four weeks treatment, effective power assessed with disease curative effect standard of group-Ⅰ was 96.88%, group-Ⅱ was 56.67%, group-Ⅲ was 6.67%. Reduction of one time blood pressure, average blood pressure of the three periods after 3days treatment and 24h dynamic blood pressure of three groups have statistical significance （P〈0.05）. Indexes of blood rule test, lung function and kidney function of three groups have no statistical significance （P〈0.05）. Conclusion： The representative prescription of TCM which was used to treat grade-Ⅱ hypertension with syndrome of hyperactivity of yang due to yin deficiency was effective.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2008年第12期1095-1098,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
云南省科技计划项目(No.2005WFX01)
关键词
2级高血压
阴虚阳亢证
方证对应
方证不对应
临床研究
Grade-Ⅱ hypertension
Syndrome of hyperactivity of yang due to yin deficiency
Correspondence of prescription-syndrome
Non-correspondence of prescription-syndrome
Clinical research
