摘要
研究目的探讨六味地黄丸与硝苯吡啶联合治疗阴虚阳亢型原发性高血压（EHT）的疗效。研究方法将75例明虚阳亢型EHT患者随机分为A、B和C三组，每组25例。25例健康人做正常对照。A组服用六味地黄龙，B组服用硝苯吡啶，C组又用上述两种药物。用药10周后检测血清中免疫球蛋白（IgG、IgA和IgM）和科体（C3）的变化及血压的波动。结果75例患者血清中的IgG及C3的平均水平高于对照组（P＜0．01）；A组患者的IgG及C3较治疗前为低（P＜0.05），而血压无变化；B组患者的免疫学上无明显变化，但血压控制较满意；C组患者血压得以理想控制，且免疫球蛋白水平降低。结论通过免疫检测和血压的理想控制两方面看，六味地黄龙与硝苯吡啶联合用药治疗阴虚阳亢型EHT是有效的，本研究为EHT的治疗提供了客观资料。
To search for the therapeutic ef fect of Liuwei rehmannia pill and nifedipine for treating essential hypertension (EHT) of types of Yang hyperactivity and Yin deficiency.Methods The 75 cases with EHT belonged to Yang hyperactivity and Yin deficlency were divided into three groups (A, B and C) randomly and each group included 25 cases. 25 normal individuls uscd to be control. Group A was treated with Liuwei rehmannia pill; group B with nifedipine; and group C with Liuwei rehmannia pill and nifedipine. After 10 weeks, the levels of immunoglobulins (IgG, IgA and IgM) and complement (C3) in serum and the changes of blood pressure (BP) were observed. The results were analysed with statistics,Results The mean levels of IgG and C3 in serum in total patients were higher than controls (P<0.01); the levels of IgG and C3 in group A were lower than previous to treatment (P<0.05),and in the group, no changs of BP was observed;In the group B, no significant change in immunology was observed (P>0.05) and the BP was controlled sahsfactorily; and, in group C, the indeal control for BP and lower levels of immunoglobulins were found.Conclutiou In the immunological aspect and the ideal control for BP, we can find that the treatment of combining Liuwei rehmannia pill with nifedipinc for EHT belonged to the types of Yang hyperactivity and Yin deficiency is effective,and it provides objective data for EHT in therapy.
出处
《新乡医学院学报》
CAS
1994年第3期279-282,共4页
Journal of Xinxiang Medical University
关键词
高血压
原发性
六味地黄丸
硝苯吡啶
阴虚阳亢
Yang hyperactivity and Yin deficiency
Liuwei rehmannia pill
nifedipine
therapy
humoral immunity
essential hypertension
