摘要
目的探讨晨尿蛋白／尿肌酐比值可否替代24h尿蛋白定量，监测尿蛋白的排泄情况。方法选取住院肾脏病患者136例，共272例尿标本，将晨尿蛋白／尿肌酐与24h尿蛋白定量进行相关性分析；采用ROC曲线分析确定晨尿蛋白／尿肌酐比值相对于24h尿蛋白定量分别大于0．15g、1．00g和3．00g的最佳诊断点。结果晨尿蛋白／尿肌酐比值与24h尿蛋白定量呈显著正相关（r=0．83，P〈0．01）；24h尿蛋白定量≥0．15g、1．00g和3．00g时，临床诊断敏感性和特异性最佳点分别为晨尿蛋白／尿肌酐比值≥0．20g／gcr，≥0．95g／ger和≥2．92g／gcr。结论晨尿蛋白／尿肌酐比值可替代24h尿蛋白定量，监测肾脏病患者尿蛋白排泄情况。
Objective To evaluate the clinical application of total protem-to-creatmme rano m first morning urine specimens as a predictor of urine protein excretion in 24-hour collections. Methods One hundred and thirty-six specimens of 24-hour urine collection and first morning urine specimens from 136 inpatients were collected. The correlations between protein-to-creatinine ratio in first morning urine specimens and urinary protein excretion in 24-hour collections were analyzed. The cutoff values of protein-to-creatinine ratio in first morning urine specimens for screening urinary protein excretion of 0. 15 g, 1.00 g and 3.00 g in 24-hour collection were determined by receiver operating characteristics （ROC） curve. Results There was a significant positive correlation between the urinary protein excretion in 24-hour collections and protein-to-creatinine ratio in first morning urine specimens. When urine protein excretion in 24-hour collections was ≥0. 15 g, ≥1.00 g and ≥3.00 g, the corresponding protein-to-creatinine ratio for best sensitivity and specificity of clinical diagnosis was ≥0. 20 g/gcr, ≥0. 95 g/gcr and ≥2. 92 g/gcr respectively. Conclusion The protein-to-creatinine ratio in first morning urine samples can used as an alternative to urine protein excretion in 24-hour collections to monitor the excretion of urine protein in the patients with renal diseases.
出处
《临床肾脏病杂志》
2008年第9期402-404,共3页
Journal Of Clinical Nephrology
