摘要
目的评价无症状性蛋白尿者用尿蛋白与尿肌酐比值（P／C）追踪随访的临床意义。方法健康体检时发现无症状性蛋白尿者检查内生肌酐清除率、24h尿蛋白定量、尿蛋白与尿肌酐比值。根据尿蛋白与尿肌酐比值大小分为3组：A组（P／C〈1．0g／gcr）、B组（P／C：1．0～3．0g／gcr）、C组（P／C〉3．0g／gcr）。根据尿蛋白肌酐比值的变化趋势分为3组：稳定组（6个月内P／C的变化在50％之内），进展组（6个月内P／C的增加〉50％），减低组（6个月内P／C的下降〉50％）。内生肌酐清除率（Cer）〈80ml／min为肾功能不全。结果107例经2～5年追踪观察，发生肾功能不全8例。其中A组发生1例，为进展组患者；B组6例，1例为稳定组患者，5例为进展组患者；C组1例，为稳定组患者。结论P／C较大、进展组的无症状性蛋白尿者发生肾功能不全较多见，对该类患者应加强随访。
Objective To evaluate the clinical value that using protein - to - creatinine ratio （P/C） trailed adult asymptomatic proteinuria. Methods Patients of adult asymptomatic proteinuria were from routine physical examination. All patients that 24 hours urinary protein quantity, creatinic cleance rate and protein - to - creatinine ratio were detected. Based on the number of protein - to - creatinine ratio, patients were divided into three groups：group A（P/C 〈 1.0g/gcr） ,group B （P/C 1.0 - 3.0g/gcr） ,group C（ P/C 〉 3.0g/gcr） ; Based on the trend of the protein- to- creatinine ratio ,patients were divided into three groups：progressive group（ the addition of P/C were more than 50% in 6 months） ,stable group （the P/C were less than 50% in 6 months）, reductive group （the decrease of P/C were more than 50% in 6 months）. Renal insufficiency was defined as creatinine clearance rate （Ccr） less than 80 ml/ rain. Results 107 patients were followed up 2 - 5 years, 8 patients were found renal insufficiency. There was 1 patient in group A, belong to progressive group. There were 6 patients in group B, 5 patients belong to progressive group, 1 patient belong to stable group. There was 1 patient in group C, belong to stable group. Conclusion If P/C was bigger or progressive group with adult asymptomatic proteinuria, these patients more likely occur renal insufficiency, advise to follow up them continuely.
出处
《医药论坛杂志》
2006年第12期22-23,共2页
Journal of Medical Forum
关键词
尿蛋白与尿肌酐比值
蛋白尿
肾功能
Protein - to - creatinine ratio
Proteinuria
Renal function
