摘要
目的：探讨非小细胞肺癌（ＮＳＣＬＣ）肿瘤新生血管与生物学行为和预后的关系。方法：随访１９８５～１９９１年间８５例原发性非小细胞肺癌术后病例，采用Ⅷ因子相关抗原免疫组化显示新生血管对其病例进行研究。结果：病人的平均年龄５５．６±８．４岁，３年、５年总体生存率分别为６６％和６１％，中位随访时间为４７个月。有淋巴结转移病人平均微血管数目为８０±３７．９，无淋巴结转移病人平均微血管数目为６５．６±３４．３，两组之间有差别（Ｆ＝３．１１，Ｐ＜０．０５）。在３１例腺癌中，有淋巴结转移组微血管数目为１０７．８±３７．３，无淋巴结转移组微血管数目为６３．９±３２．７，两组之间有显著性差别（Ｆ＝１０．５４，Ｐ＜０．０１），单变量生存分析显示，随着微血管数目的增加，病人的生存率明显下降（Ｐ＜０．０１）。结论：新生血管密度与非小细胞肺癌（ＮＳＣＬＣ）的生物学行为有关并有重要的预后意义。
Purpose In order to study the relationship between tumor angiogenesis and biological behavior and prognosis in nonsmall cell lung cancer (NSCLC). Methods 85 cases from resected primary NSCLC in 1985￣1991 were followedup and studied by immunostaining of angiogenesis with Ⅷ factor related antigen showing endoepithelium cells. Results The patients mean age was 556±84 years. Median followup was 47 months. Overall 3year survival was 66% and overall 5year survival was 61%. Mean microvessel counts were 80±379 and 656±343 in the group with lymph node metastasis and the group without lymph node metastasis, respectively. The difference between the two groups was statistically significant (F=311, P<005). In 31 cases lung adenocarcinoma, mean microvessel count of the patients group with lymph node metastasis was 1078±373 and that of the patients group without lymph node metastasis was 639±327. The difference between the two groups was statistically significant (F=1054,P<001). Univariate survival analysis revealed that there was a trend of significantly (P<001) decreasing survival proportion with increasing mirovessel count. Conclusions There is a relationship between angiogenesis density and aggressive behavior in nonsmall cell lung cancer, and angiogenesis density has important prognostic significance.
出处
《临床与实验病理学杂志》
CAS
CSCD
1997年第4期308-310,I030,共3页
Chinese Journal of Clinical and Experimental Pathology
关键词
血管组织
非小细胞肺癌
转移
预后
肺肿瘤
neovascularisation
nonsmal cell lung cancer
metastasis
prognosis
