摘要
交配型转换/蔗糖不发酵(SWI/SNF)复合体介导的ATP依赖性染色质重塑是机体最基本的生物学过程,对转录、复制、损伤修复、染色体重组及有丝分裂等DNA代谢过程有关键的调控作用。近年来多项研究表明SWI/SNF复合体可通过多种途径参与前列腺癌发病及演进过程,如细胞周期调控、雄激素受体途径及DNA甲基化等。本文简要综述了近年来SWI/SNF复合体与前列腺癌关系的研究进展。
ATP-dependent chromatin remodeling by the mating type switching/sucrose non-fermenting （SWI/SNF） complex is a basic biological event in the body, which is required for all the key processes involved in DNA metabolism such as gene expression, DNA replication, repair, chromosomal recombination and mitosis. In the past few years, increasing evidence supports a crucial role of this complex in prostate cancer development and progression via multiple ways, such as cell cycle regulation, androgen receptor pathway and DNA methylation. The present paper briefly reviews the recent studies on the association between the SWL/SNF complex and prostate cancer. Natl J Androl, 2008, 14 （10） ： 935-938
出处
《中华男科学杂志》
CAS
CSCD
2008年第10期935-938,共4页
National Journal of Andrology
