摘要
目的:探讨PTEN在乳腺癌中表达及与肿瘤血管生成的关系。方法:用免疫组化SP法检测53例乳腺癌和10例乳腺良性增生中PTEN,并测定微血管密度(MVD)。结果:PTEN在良性乳腺增生中高表达率为100%(10/10),在乳腺癌中高表达率为49.1%(26/53)(P<0.01)。腋窝淋巴结转移阳性组的PTEN的低表达率为的表达63.3%(19/30),明显高于腋窝淋巴转移阴性组34.8%(8/23)(P<0.05)。雌激素受体(ER)阴性组PTEN低表达率为72.0%(18/25),明显高于雌激素受体阳性组(P<0.05)。PTEN的表达与MVD呈负相关(P<0.05)。结论:在乳腺癌中PTEN表达下调及丢失预示乳腺癌血管生成及淋巴结转移。
Objective：To investigate the expression of PTEN（phosphatase and tensin hmmlogy deleted on ten） in the breast cancer and the relationship with the tumor angiogenesis.Methods：The expression of PTEN and MVD were detected by immunohistochemical SP method in paraffin section from 53 women with primary breast cancer and 10 subjects of hyperplasia of mammary glands.Results：The higher lever PTEN expression in 53 case with the rate 49.1 %（26/53）,which was reduced compared with the expression in benign hyperplasia of mammary glands（P〈0.01）.The lower lever expression of PTEN rate was higher in the group of axillary lymph node metastasis case than that of the case without lymph node metastasis（P〈0.05）.The lower lever PTEN expression rate was higher in the group of estrogen receptor negative status than that of the estrogen receptor positive status（P〈0.01）.The lower lever PTEN expression was related with higher MVD（P〈0.05）.Conclusion：The expression reduce or loss of PTEN may related with tumor angiogenesis and axillary lymph node metastasis in breast cancer.
出处
《医学研究生学报》
CAS
2008年第10期1067-1069,1073,I0001,共5页
Journal of Medical Postgraduates
