摘要
目的调查福建省宁德市青山岛居民幽门螺杆菌(Hp)感染率,了解该地区Hp菌株耐药率并与福建省立医院门诊病人菌株耐药率比较。方法用13C尿素呼气试验检测有无Hp感染。对感染者行胃镜检查,胃黏膜活检培养Hp菌株。用E试验法和琼脂稀释法检测阿莫西林、克拉霉素、甲硝唑的耐药性。结果该地区的Hp感染率为52.5%,存在家庭聚集现象。感染率随着年龄增长而增加。其Hp菌株甲硝唑耐药率为11.4%,克拉霉素耐药率为5.7%,无阿莫西林耐药菌株。福建省立医院门诊病人Hp菌株甲硝唑耐药率66.7%,克拉霉素耐药率为26%,无阿莫西林耐药菌株。结论由于无抗生素滥用,宁德市青山岛Hp对克拉霉素、甲硝唑耐药率明显低于福建省立医院门诊福州市区病人。
Objective To investigate the prevalence of Helicobacter pylori infection and of antibiotic resistance of Helicobacter pylori on Qingshan island,Ningde city of Fujian province and compared the frequency of antibiotic resistance with Fujian Provincial Hospital. Methods Helicobacter pylori infection was determined with 13C urea breath test. Endoscopic examination collected biopsy specimens and isola- ted H pylori strains. The MICs of amoxicillin ,clarthromycin, metronidazole were determined by the Etest. Results The overall prevalence of Helicobacter pylori infection was 52.5%. Prevalence of Heli- cobacter pylori infection increased with age. Helicobaeter pylori infection was intrafamilial clustering. The prevalence of metronidazole resistance was 11.4% and the prevalence of clarthromycin resistance was 5.70/00 and no amoxicillin-resistance strain was found in the strains isolated from Qingshan island. The prevalence of metronidazole resistance was 66% and the prevalence of clarthromycin resistance was 26% in the strains isolated from out-patients in Fujian provincial hospital. Conclusion The prevalence of Helico- bacter pylori antibiotic resistance is very low in the area where the antibiotic is not widely used.
出处
《福建医科大学学报》
2008年第5期422-424,共3页
Journal of Fujian Medical University
关键词
螺杆菌
幽门
螺杆菌感染
抗药性
细菌
药物耐受性
福建
helicobacter pylori
helicobacter infections
drug resistance, bacterial
drug tolerance
Fujian
