摘要
目的调查研究新疆地区汉维两族幽门螺旋杆菌(Helicobacter pylori,H.pylori)临床分离菌株对左氧氟沙星耐药现状。方法应用E-test法检测60株H.pylori菌株(汉维各30株)对左氧氟沙星耐药率。结果新疆地区H.pylori临床分离菌株对左氧氟沙星耐药率为41.67%。汉维两族H.pylori对左氧氟沙星耐药率差异无统计学意义(P>0.05);不同性别、年龄、疾病的H.pylori对左氧氟沙星耐药率的差异无统计学意义(P>0.05)。结论新疆地区H.pylori对左氧氟沙星耐药率相对较高,在H.pylori的根除方案中尽量避免选择左氧氟沙星。在选择H.pylori根除治疗的抗生素时可以忽略汉维两族之间的差异。
Objective To investigate the antimicrobial agents resistant status of Helicobacter pylori （H. pylori） to levofloxacin, which isolated from patients suffered with upper gastrointestinal diseases and the relationship between the antimicrobial agents resistance and nation （Uighur and HaM nationality） in Xinjiang area. Methods E-test method was used to detect 60 strains of H. pylori （30 H. pylori strains from HaM and 30 H. pylori strains from Uighur） to levofloxacin resistance rate. Results In 60 cases of H. pylori strains, the aoverall levofloxacin resistance rate was 41.67%. There was no significant difference （P 〉 0.05） in the levofloxacin resistance rate of H. pylori between Uighur and HaM nation- ality ; the rates of levofloxacin resistance on H. pylori among different gender, age and diseases had no significant differ- ences （P 〉 0.05）. Conclusion The rate of levofloxacin resistance on H. pylori in Xingjiang area was relatively high, and it is better to avoid the selection of levofloxacin in the H. pylori eradication programme. The difference between Uighur and HaM nationality can be ignored in the selection of antibiotics in H. pylori eradication therapy.
出处
《胃肠病学和肝病学杂志》
CAS
2013年第3期237-239,共3页
Chinese Journal of Gastroenterology and Hepatology
