摘要
目的探讨卵巢癌组织中RhoC蛋白的表达水平及其临床意义。方法采用免疫组织化学S-P法,检测96例卵巢癌患者卵巢癌组织中(卵巢癌组)RhoC蛋白的表达情况,并与卵巢良性肿瘤组织(卵巢良性肿瘤组)和正常卵巢组织(正常对照组)进行比较。结果卵巢癌组、卵巢良性肿瘤组和正常对照组的RhoC蛋白表达情况间差异有统计学意义(P<0.05)。不同组织学分级的卵巢癌组织中,RhoC蛋白的表达情况间差异有统计学意义(P<0.05);不同临床分期的卵巢癌组织中,RhoC蛋白的表达情况间差异有统计学意义(P<0.05);不同病理类型的卵巢癌组织中,RhoC蛋白的表达情况间差异无统计学意义(P>0.05)。结论卵巢癌组织中RhoC蛋白表达水平较高,并与肿瘤的组织学分级、临床分期有关。
Objective To study on the expression level of RhoC protein in ovarian cancer tissue and its clinical significance. Methods By immunohistochemistry streptavidin -perosidase （SP） method, the expression of RhoC was detected in 96 ovarian cancer patients, ovaries benign tumor patients and health volunteers. Results The positivity rates of RhoC protein in ovaries tissue in patients with ovarian cancer was obviously higher than those in patients with benign tumor and health subjects （ P 〈 0. 05 ）. The positivity rates of RhoC protein in well, moderately and poorly differentiated cancer presented a significant difference （ P 〈 0.05 ）. The positivity rates of RhoC protein in Ⅰ , Ⅱ , Ⅲ and Ⅳ stages presented a significant difference （ P 〈 0. 05 ）. But the positivity rates of RhoC protein showed no significant difference in different pathological tissue types （ P 〉 0. 05 ）. Conclusion The expression of RhoC protein is higher in ovarian cancer tissue, and it is associated with differentiation grade of tumor and clinical stage.
出处
《中国全科医学》
CAS
CSCD
2008年第21期1937-1938,共2页
Chinese General Practice
关键词
RHOC
卵巢癌
表达
RhoC
Ovarian cancer
Expression
