摘要
目的:探讨银杏叶提取物(extract of Gingko biloba leaves,EGB)对衰老小鼠学习、记忆障碍的改善作用及其作用机制。方法:将33只雄性小鼠分为3组,每组11只。即模型组:按300mg/kgBW剂量腹腔注射D-半乳糖,1次/d;治疗组:在按上述剂量注射D-半乳糖的同时,按15mg/kgBW剂量腹腔注射EGB,1次/d;对照组:按上述同样剂量注射生理盐水溶液,1次/d。所有实验处理进行6周后停止给药,用Y式迷宫、跳台法检测小鼠的学习记忆能力,同时测定肝、脑组织的单胺氧化酶(monoamine oxidase,MAO)活性。结果治疗组的学习、记忆成绩均显著高于模型组,差异都具有统计学意义(P<0.05或P<0.01)。结论:EGB对于衰老小鼠的学习、记忆障碍有明显的改善作用,在其作用机制中,MAO发挥了重要作用。
Objective： To study the effect and mechanism of extracts of Gingko biloba leaves（EGB）on the improvement of learning and memory disturbance in senile mice. Methods Thirty-three male mice were randomly divided into 3 groups, 11 mice in each group. Mice in model group were injected with D-galactose （300 mg/kg BW） by celiac injection once a day, and the mice in treatment group were injected with D-galactose （300 mg/kg BW）and EGB （15 mg/kg BW） at the same time. The mice in normal group were injected with the same volume of physiological saline solution. After treatment for 6 weeks, the learning and memory ability of mice in each group were determined with Y-maze test and step-down test, and the monoamine oxidase （MAO） activity in liver and brain tissue was tested at the same time. During the test, the celiac injection was stopped. Results： The ability of learning and memory in treatment group was significantly higher than that in model group （P〈0.05 or P〈0.01）. Conclusion： EGB could improve learning and memory disturbance in senile mice and MAO probably plays an important role in the metabolic process.
出处
《食品科技》
CAS
北大核心
2008年第10期271-273,共3页
Food Science and Technology
关键词
银杏叶提取物
学习记忆障碍
改善
extracts of Gingko biloba leaves （EGB）
learning and memory disturbance
improvement
