摘要
目的了解西南地区医院临床分离菌对常用抗菌药物的耐药性。方法西南14家医院的分离菌株按统一方案进行抗菌药物敏感试验，按CLSI 2006年版判断结果。结果14家医院2006年6月～2007年5月各种临床标本中分离菌株共13937株，革兰阳性菌占28．7％，革兰阴性菌占71．3％。葡萄球菌中MRSA和MRCNS检出率分别为36．3％和55．5％。粪肠球菌对替考拉宁和万古霉素敏感，敏感率为98．4％和88．6％。肠杆菌科细菌均对亚胺培南高度敏感，耐药率最低。大肠埃希菌、肺炎克雷伯菌、奇异变形菌产ESBLs株分别占53．7％、57．7％和68．7％。鲍曼不动杆菌对亚胺培南的敏感率为80．7％，铜绿假单胞菌对阿米卡星敏感率较高为64．3％。嗜麦芽寡养单胞菌对大多数抗菌药物耐药率＞50％。结论细菌耐药性呈增长趋势，定期进行耐药性监测有助于了解细菌耐药性情况，为临床用药提供参考。
Objective To investigate the resistance of clinical isolates of southwest China. Methods 14 hospitals in southwest China were involved in this program. Bacterial susceptibility test was performed according to an agreed protocol using Kirby-Bauer method. Results were analyzed according to CISI 2006. Results A total of 13,937 clinical isolates were collected from June 2006 to May 2007. Gram positive microorganisms and Gram negative microorganisms accounts for 28. 7% and 71.3% respectively. In Staphylococcus, about 36.6% were methicillin-resistant S. aureus （MRSA）, 55.5% were methicillin-resistant coagulase-negative Staphylococcus. About 98.4% and 88.6% of E. faecalis isolates were susceptible to teicoplanin and vancomycin respectively. Enterobacteriaceae strains were highly susceptible to imipenem with the lowest resistance rates. 53.7% of Escherichia coli, 57. 7% of Klebsiella pneurnoniae and 68.7% of Proteus mirabilis were ESBLs producers. Acinetobacter baumannii was susceptible to imipenem （80. 7%）. Pseudomonas aeruginosa was relatively susceptible to amikacin （64.3%）. The resistance rates of S. maltophilia to most of the antimicrobial agents were over 50%. Conclusions The bacterial resistance was still on the rise. Regular surveillance of antimicrobial resistance was valuable for understanding the trend of antimicrobial resistance and provide the guidance for clinical choosing of antimierobial agents.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
2008年第10期622-628,共7页
Chinese Journal of Antibiotics
