摘要
目的建立测定盐酸硫必利片溶出度方法。方法采用中国药典2005年版二部附录XC溶出度测定第一法，以0．1mol·L^-1盐酸为溶媒，转速为75r·min^-1，取样时间为30min，在287nm波长处测定其溶出度。结果盐酸硫必利检测浓度的线性范围为16～144μg·mL^-1（r=0．9999）；平均回收率为98．77％，RSD=0．3%（n=9），7批样品30min溶出度均在90％以上。结论本方法操作简便，结果准确，可用于盐酸硫必利片的溶出度测定。
Objective To establish a dissolution method for tiapride hydrochloride tablets. Methods Dissolution of tiapride hydrochloride tablets was determined by the solvent according to the method in Chinese Pharmacopoeia with 0. 1 mol · L^- 1 hydrochloric acid as the solvent at a rotation speed of 75 r · min^- 1. The sampling time was 30 min and the detection wavelength was 287 nm. Results The linear range of tiapride hydrochloride was 16-144 μg · mL^-1 （r= 0. 999 9） and the average recovery was 98. 77%. RSD =0. 3% （n=9）. The dissolution of 7 batches.of samples was all above 90%. Conclusion The method is simple, accurate, and it is suitable for the dissolution of tiapride hydrochloride.
出处
《中南药学》
CAS
2008年第5期566-568,共3页
Central South Pharmacy
关键词
盐酸硫必利片
溶出度
紫外分光光度法
tiapride hydrochloride tablets
dissolution
UV spectrophotometry
