摘要
In this article, poly（2-hydroxyethylmethacrylate-co-acrylamide） hydrogels were synthesized by bulk free-radical copolymerization of 2-hydroxyethylmethacrylate （HEMA） and acrylamide （AAm） for soft contact lens（SCL）-based ophthalmic drug delivery system. The copolymer was characterized with FT-IR and SEM, the swelling property of the hydrogels were studied by gravimetrical method, and chloramphenicol was used as a model drug to investigate drug release profile of the hydrogels. The results showed that poly（2-hydroxyethylmethacrylateco-acrylamide） hydrogels were transparent and useful SCL biomaterial, the water content increased as AAm content increase and pH decrease, and in the same way, hydrogel composition affected chloramphenicol release process too. Migration rate of chloramphenicol increased as the AAm content in the hydrogels increased in the first stage of diffusion process, whereas there was no significant difference thereafter.
在这篇文章，(2-hydroxyethylmethacrylate-co-acrylamide ) poly， hydrogels 被 2-hydroxyethylmethacrylate (HEMA ) 和为软接触透镜(SCL ) 的 acrylamide (AAm ) 的免费激进分子的 copolymerization 基于的体积综合眼的药交货系统。共聚物与英尺红外和 SEM 被描绘， hydrogels 的胀大的性质被 gravimetrical 方法学习，并且氯霉素被用作调查 hydrogels 的药版本侧面的模型药。结果 poly 显示出那(2-hydroxyethylmethacrylate- co-acrylamide ) hydrogels 是透明、有用的 SCL biomaterial，作为 AAm 内容增加增加的水内容和 pH 减少，并且以一样的方法， hydrogel 作文也影响了氯霉素版本过程。当在 hydrogels 的 AAm 内容在散开过程的第一个阶段增加了，氯霉素的迁居率增加了，而此后没有重要差别。
基金
Supported by the Natural Science Foundation of Guangdong Province （5300978） and Zhongkai University of Agriculture and Engineering （G2360221）.
