摘要
The stereoselective syntheses of (-)-chloramphenicol, (+)-thiamphenicol and (+)-sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.
The stereoselective syntheses of (-)-chloramphenicol, (+)-thiamphenicol and (+)-sphinganine are described. The two continuous chiral centers within three target molecules were constructed through aldol reaction of chiral tricyclic iminolactone and aldehyde.
基金
Acknowledgement We are grateful for the National Basic Research Program of China (No. 2011CB833200), the National Natural Science Foundation of China (Nos. 20772051, 20972058), the "111" Program from MOE of P. R. China and the Fundamental Research Funds for the Central Universities (lzujbky-2012-90).