摘要
目的了解类风湿性关节炎(RA)血清中转化生长因子(TGF-β1)和基质金属蛋白酶(MMP-8)的变化。方法采用ELISA方法测定RA患者血清TGF-β1和MMP-8的浓度。结果RA血清血清TGF-β1较正常组浓度低,而MMP-8则较正常组值高,差异有统计学意义(P<0.05)。结论TGF-β1和MMP-8参与了RA的发生和发展过程,在RA慢性炎症过程中,对炎细胞转移并聚集于滑膜可能有重要作用。
Objective To explore the chang of transforming growth factor-β1 and matrix metalloproteinase-8 in sera.Methods The expression of TGF-β1,MMP-8 in sera in patients with RA was measured by ELISA method.Results The contents of serum TGF-β1 in patients with RA were lower than those in normal subjects.But the contents of serum MMP-8 in patients with RA were higher.Conclusion TGF-β1 and MMP-8 take part in the occurrence or development course of RA.Its plays an important role in inflammatory cell transforming and aggregating to synovial tissue.
出处
《临床医学》
CAS
2008年第7期110-111,共2页
Clinical Medicine
关键词
类风湿性关节炎
转化生长因子
基质金属蛋白酶
Arthritis rheumatoid
Transforming growth factor-β1
Matrix metalloproteinase-8
