摘要
目的:探讨那格列奈治疗2型糖尿病的疗效。方法:2型糖尿病患者62例,随机分为两组。那格列奈组30例,格列吡嗪组32例,两组年龄、性别匹配具有可比性,疗程均为12周。观察两组空腹血糖、餐后2h血糖、胰岛素、糖化血红蛋白等变化及不良反应。结果:两组治疗后空腹血糖、餐后2h血糖和糖化血红蛋白(HbAIC)均明显下降,差异有显著性(P<0.01);两药降低空腹血糖幅度无统计学意义,而对餐后2h血糖的疗效那格列奈高于格列吡嗪(P<0.01),那格列奈降低HbAIC疗效优于格列吡嗪(P<0.05),那格列奈能刺激胰岛素分泌,口服后2h血浆胰岛素浓度高于格列吡嗪。结论:那格列奈和格列吡嗪对空腹血糖均有显著性下降,那格列奈控制餐后高血糖和降低HbAIC明显优于格列吡嗪。
Objective：To explore the effect and adverse reactions of nateglinide in treating type 2 diabetes and its effect on insulin secretion.Methods：67 patients with type 2 diabetes were divided into two groups,the nateglinide groups （n=30） and the glipizide groups （n=32）.The age and sex of two groups is match,for 12 weeks.The observation of two groups was made on the changes and adverse reactions of fasting blood glucose （FBG）,postprandial blood glucose （PBG）,blood lipid,insulin,HbAIc and others.Results：After the treatment of two groups,the levels of FBG,PBG and HbAlc lowered significantly （P〈0.01）;the reduced FBG rate of both drugs was not statistically significant（P〉0.05）,but nateglinide than glipizide（P〈0.01） in 2h after PBG;the effect reducing HbAIc of nateglinide than that of glipizide （P〈0.05）;nateglinide could stimulate insulin secretion, the plasma insulin concentrations after two hours of oral was higher than glipizide. Conclusion：Domestic repaglinide is an effective and less adverse reactions and safe drug in treating type 2 diabetes.
出处
《现代医药卫生》
2008年第15期2229-2230,共2页
Journal of Modern Medicine & Health
