摘要
目的:探讨甘精胰岛素与那格列奈联合治疗初发型2型糖尿病患者的临床疗效。方法:回顾性分析笔者所在医院2011年12月-2013年12月收治的57例初发型2型糖尿病患者的临床资料,予以患者甘精胰岛素,1次/d,行皮下注射,控制空腹血糖,同时联合使用那格列奈,控制餐后2 h血糖,持续治疗2个月,观察患者空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)变化以及治疗前后OGTT各时点C肽与血清INS发展状况。结果:治疗后HbA1c、FPG、2 h PG均显著下降,与治疗前比较差异均有统计学意义(P<0.05);治疗后患者0.5 h、1 h C肽与0.5 h、1 h INS显著上升,与治疗前比较差异均有统计学意义(P<0.05);服糖前、服糖后2 h、3 h C肽与INS治疗前后比较差异无统计学意义(P>0.05)。结论:甘精胰岛素与那格列奈联合治疗初发型2型糖尿病患者疗效颇佳,能显著改善患者胰岛素Ⅰ相分泌,值得临床广泛推广与应用。
Objective：To observe the clinical efficacy of insulin glargine combined with nateglinide in treatment of type 2 diabetes patients. Method： Retrospective analysis of our hospital from December 2011 to December 2013 were treated 57 cases of clinical data of patients with early onset type 2 diabetes, insulin glargine to patients, 1 times daily, subcutaneous injection, the control of fasting blood glucose, and combined use of nateglinide, 2h postprandial glucose control, continuous treatment for 2 months, observed in patients with fasting blood glucose （FPG）, 2h postprandial blood glucose （2hPG）, glycosylated hemoglobin （HbA1c） and the changes of OGTT before and after treatment in each time C peptide and serum INS development.Result： Compared with those before treatment, after treatment of patients with HbA1c, FPG and 2h PG measured value statistically decreased, 0.5h increased significantly, 1h C peptide and 0.5h, 1h INS, and the difference were all statistically significant（P〈0.05）. C peptide and INS before taking sugar,2 h after taking sugar,3 h after taking sugar after treatment compared with those before treatment had no significant change（P〉0.05）.Conclusion： Patients with good effect of insulin glargine combined with nateglinide in treatment of type 2 diabetes patients with insulin, can significantly improve theⅠphase secretion, is worthy of extensive promotion and application.
出处
《中外医学研究》
2014年第17期6-7,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
