摘要
目的:探索不同时期瘢痕组织内透明质酸含量,含水量与它们之间的关系。方法:收取2年以内及2年以上的烧伤后增生性瘢痕的真皮组织,取正常皮肤真皮作为对照,测量其含水量,用Elisa法检测透明质酸含量,求出它们之间的相关系数以了解它们之间的关系。结果:正常皮肤含水量69.59%,2年以内的烧伤后增生性瘢痕为69.88%,2年以上为71.40%,差异无统计学意义(P>0.05);透明质酸在正常皮肤中不能测出,在2年内瘢痕中的含量为1.70±0.54μg/ml,2年以上为3.36±0.08μg/ml,二者比较差异有统计学意义(P<0.01);透明质酸含量与含水量之间无相关关系(γ=0.27,P>0.05)。结论:随着瘢痕形成时间的延长,透明质酸含量增加,可能与瘢痕成熟有关,含水量在正常皮肤、2年以内及2年以上瘢痕间相似,透明质酸量的变化没有相应地导致含水量的变化。
Objective： To investigate hyaluronic acid contents, water contents of hypertrophic scars in different periods and correlation of them. Method： Demis of normal skins and hypertrophic burn scars less and more than 2 years was harvested. Water contents were measured, and Elisa was performed to assay hyaluronic acid contents, and related coefficiency of them was estimated to identify the correlation between them. Result：There were no statistical differences in water contents along normal skin, hypertrophic scars less and more than 2 years （P〉0.05）. Hyaluronic acid content of normal skin couldn＇t be measured out, those of hypertrophic scars less and more than 2 years were 1.70± 0.54μg/ml and 3.36±0.08μg/ml, respectively, and was statistically different （P〈0.01）. There was no correlation between water and hyaluronic acid content （γ=0.27, P〉0.05）. Conclusion： Hyaluronic acid content of hyper-trophic scar will increase with elongation of scar period and may be related to scar mature. Normal skin, hypertrophic scars less and more than 2 years contain similar water contents. The change of hyaluronie acid content couldn＇ t result in that of water content in hypertrophic sear.
出处
《赣南医学院学报》
2008年第3期324-325,349,共3页
JOURNAL OF GANNAN MEDICAL UNIVERSITY
基金
杭州师范大学重点课题基金(2004XYZ04)资助
关键词
透明质酸含量
含水量
增生性瘢痕
Hyaluronic acid content
Water content
Hypertrophic scar
