摘要
目的:检测喉鳞状细胞癌组织中APC蛋白的表达情况并分析其与临床病理特征的关系。方法:采用免疫组织化学SP法检测61例喉鳞状细胞癌(男59例,女2例;声门上型17例,声门型44例;<60岁38例,≥60岁23例;T1～T2期32例,T3～T4期29例;病理学分级Ⅰ级17例,Ⅱ～Ⅲ级44例;有淋巴结转移11例,无淋巴结转移50例)和10例喉正常黏膜组织中APC蛋白的表达。结果:喉鳞状细胞癌和喉正常黏膜组织中APC蛋白的阳性表达率分别是21.3%和80.0%,差异有统计学意义(P<0.01)。且喉鳞状细胞癌组织中APC蛋白的阳性表达率与病理学分级、T分期有关(P均<0.05)。结论:APC蛋白与喉鳞状细胞癌的发生密切相关,可作为喉鳞状细胞癌发生和预后的检测指标。
Aim ： To detect the expression of APC protein in human laryngeal squamous cell carcinoma（LSCC） tissue, and explore its relationship with clinic opathological feature. Methods ：Expression of APC protein was detected in 61 cases of LSCC （59 cases of male, 2 cases of female; 17 cases of supraglottic carcinoma, 44 cases of glottic carcinoma; 38 cases of 〈60 years old, 60 cases of ≥60 years old; 32 cases of stage TE and T2 , 29 cases of stagc T3 and T4 ; 17 cases of grade Ⅰ , 44 cases of grade Ⅱ and Ⅲ ; 11 cases with lymph node metastasis,50 cases without lymph node metastasis） using im- munohistochemistry method and 10 cases of normal laryngeal mucosa tissue. Results： The positive expression rate of APC protein was 21.3% and 80.0% in LSCC and normal laryngeal mucosa tissue（ P 〈 0,. 01 ）. The positive expression rate of APC was correlated with pathological grade and T stages（ P 〈 0.05 ）. Conclusion ： APC protein is associated with tumorigenesis of LSCC, and may be a potential predictor of histological diagnosis in LSCC.
出处
《郑州大学学报（医学版）》
CAS
北大核心
2008年第4期716-718,共3页
Journal of Zhengzhou University(Medical Sciences)
关键词
喉肿瘤
鳞状细胞癌
APC
laryngeal neoplasm
squamous cell carcinoma
APC
